Ceramide levels in the treatment and prevention of infections
AssigneesIcahn School of Medicine at Mount Sinai, Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
InventorsEdward H. Schuchman, Erich Gulbins, Anthony Futerman, Yael Pewzner-Jung
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Abstract
The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.
Claims20
A method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound, said method comprising:
- selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and
- administering to said selected subject a ceramidase under conditions effective reduce ceramide and to treat or prevent said pathogenic infection in said selected subject.
Dependencies are inferred from the claim text.