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US 2025/0179217 A1Published application
Enhanced Immunogenicity For GPI-anchored Antigens
AssigneeNantBio, Inc.
InventorsKayvan Niazi, Wael Tadros, Annie Shin
Life of this patent
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Abstract
Compositions and methods are presented that allow for an enhanced immune response against a GPI-anchored tumor associated antigen by modification of the protein portion of the TAA to include a transmembrane domain and a trafficking signal that directs the modified protein to the endosomal or lysosomal compartment. Most preferably, the modified protein will no longer have a GPI anchor or GPI attachment sequence.
Claims20
A method of increasing antigenicity of a glycophosphatidylinositol (GPI)-anchored protein, comprising:
- modifying the protein portion of the GPI-anchored protein to include at least one transmembrane domain and a trafficking element, and wherein a GPI anchor signal sequence of the glycophosphatidylinositol (GPI)-anchored protein is removed or modified to abolish or render GPI binding less efficient;
- and
- wherein the trafficking element directs the modified protein to a sub-cellular location selected from the group consisting of a recycling endosome, a sorting endosome, and a lysosome.
Dependencies are inferred from the claim text.