Use Of Chemokine Receptors In Cellular Homing

Abstract

Aspects of the present invention relate to the use of chemokine receptors such as e.g., CCR4 and CCR6, as homing agents. The chemokine receptor(s) is/are expressed by cells containing synthetic chromosomes. The chemokine receptor(s) is/are under controllable expression from a synthetic chromosome and can be used to control an immune response so as to treat or inhibit a disease such as cancer. The control is provided by inducing leukocyte trafficking to sites of disease. If more than one chemokine receptor is expressed, the levels can be individually controlled so that the desired cellular trafficking pattern can be obtained.

Dependencies are inferred from the claim text.