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US 2025/0179004 A1Published application
Processes and intermediates for preparing mcl1 inhibitors
AssigneeGilead Sciences, Inc.
InventorsDarryl D. Dixon, Michael A. Ischay, Trevor C. Johnson, Jeffrey E. Merit, Christopher S. Regens, Eric A. Standley, Dietrich P. Steinhuebel
Life of this patent
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Abstract
The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.
Claims9
1-9. (canceled)
A method of preparing a compound of formula 1-Q:
- or the salt thereof, by reacting a corresponding compound of formula 1-P:
- with a corresponding compound of formula 1-I:
- to provide the compound of formula 1-Q;
- wherein Rx is H or C1-6alkyl;
- R5 is CH3;
- Rz is halogen or CN.
3 more elements
17-23. (canceled)
Dependencies are inferred from the claim text.