Analyte depletion for sensor equilibration
OwnerIan Harmoninventor
Life of this patent
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Abstract
Methods include treating a portion of a sample composition to be tested for presence of an analyte by depleting or blocking the target analyte. The treated composition may be used to equilibrate an acoustic wave sensor prior to exposing the sensor to the untreated sample composition for analysis. By using the treated sample composition, in which the analyte is depleted or blocked, to equilibrate the sensor, the sensor may be equilibrated with a composition having a similar viscosity and non-specific binding characteristics to the untreated sample composition, which should result in improved accuracy when analyzing the analyte in the untreated sample composition.
Claims20
A method for evaluating analyte presence comprising:
- providing a composition to be tested for the presence of an analyte;
- contacting a first portion of the composition with a material configured to reduce detectable analyte in the composition;
- and
- flowing the first portion of the composition over a surface of a sensor, wherein an analyte capture material is located at the surface of the sensor.
A device for evaluating analyte presence, comprising:
- a sensor having an analyte capture material located thereat;
- a first fluid flow path positioned upstream of the sensor, configured to transport a first amount of a composition to be tested for analyte presence to the sensor;
- a material configured to reduce detectable analyte in the composition;
- wherein the material configured to reduce detectable analyte in the composition is positioned in the first fluid flow path.
A method for equilibration of a sensor for testing the presence of an analyte, comprising:
- providing a composition to be tested for the presence of the analyte;
- contacting a first portion of the composition with a material configured to reduce detectable analyte in the composition;
- and
- flowing the first portion of the composition over a surface of the sensor to equilibrate the sensor for testing the presence of an analyte in a second portion of the composition.
Dependencies are inferred from the claim text.