Synthetic planning of robotic arc therapy (sprat)

A device comprising:

• a. a mechanically distributed energy radiating source, which is external and around a body, or head, to treat and image pathologic lesions;
• b. wherein the radiated energy is ionizing, ablating electromagnetic kV ranging from 100-350 kVp;
• c. wherein the radiated energy source's orientation comprises a combination of directing ionizing output or beams at an internal lesion as a result of movement selected from the group consisting of rotation around an isocenter in a single plane or multiple planes, static or arcing beams shifted closer or further from the skin and lesion, non-coplanar delivery from any direction external to a body originating in a concentric sphere around a targeted lesion, or altering the radiation source's distance from the lesion along radials originating in the targeted lesion;
• d. wherein the energy is delivered non-invasively without employing a device or mechanism to cut, puncture or traumatically penetrate skin or other surface, and without an open surgical procedure;
• e. wherein an energy-emitting source is aligned in a localized, or circumferential, or ring or spherical distribution around a patient, as a stand-alone arrangement following radials originating in a treated tumor, or in a surface conforming layout, or moved by a robot and not requiring a circular gantry;
• f. wherein a phased array of positions of the ionizing energy source is electronically or computer controlled, to shift and contour its output or beams in different directions by mechanically moving the source in space, for discrete and localized delivery of energy dose to a given depth or lateral position in the body with a narrow or focused distribution in a lesion;
• g. wherein the resulting contoured energy output or beams need not be isocentric, but are converging electromagnetic kV energy beams and deposit energy dose in a localized volume of interest to treat pathologic tissue;
• h. wherein the conforming volume of prescribed x-ray dose is discrete, encompassing and customized to a detrimental phase or lesion within the body, thereby enhancing restoration by controlling parameters to a normal physiologic range and thus enabling a healthy transition state;
• i. electronic or computerized controls for source and system operation with a connected power supply and cooling;
• j. a medium storing computer-executable process steps to reconstruct medical images and calculate and optimize therapeutic effects of the localized treatment with ionizing kV radiation;
• and
• k. real-time, non-invasive x-ray source beam output measurement.

A method comprising:

• a. effective and deliberate targeting to non-invasively deliver ionizing, ablating, kV electromagnetic energy beams to specific volumes of tissue or locations inside a body or head, wherein the energy targeting is measured and evaluated in real time with imaging, fiducial localization or other functional registration;
• b. wherein the ionizing kV energy output is effectively directed according to optimized dose gradient vectors towards a desired location, specific or selected volume, and energy waves traveling towards undesired locations, such as healthy tissue, are quenched;
• c. obtaining an original condition, state, conformation, functionality or phase in the body by introducing adequate localized energy to a pathologically altered tissue, network or system;
• d. wherein the energy is focused, enhanced and localized energy, and reverses or destroys malignant tissue thereby enabling restoration to their native, normal conformation;
• e. wherein the beams' variables and parameters, which are optimized for a three-dimensional gradient field, include but are not limited to, energy, spectrum, filtration, field size, location and orientation in stereotactic space or volume, source-to-skin distance (SSD), generating amperage (mA) and time of delivery, beam shape and collimation, and number and location of beam overlaps, consideration of attenuation for a given beam energy and effects of the inverse square law (1/r{circumflex over ( )}2) and inverse cube law (1/r{circumflex over ( )}3);
• f. wherein the variables and parameters of the focused, enhanced and localized ionizing dose or other energy deposition are optimized as gradient vectors or gradient vector fields;
• g. wherein the multiple beams, considered as radial vectors or steradian-associated vectors herein, are focused towards a location targeted in space and time, to deliver effective low-energy ionizing teletherapy;
• h. inducing a salutary effect in a diseased tissue comprising a combination of enhancing degradation, elimination, enhancing immune processing and antigen presentation of peptide elements;
• and
• i. wherein the induced effects of focused, enhanced and localized ionizing energy deposition further comprise a combination of enhancing tissue repair and removing tumors internally, each treating a diseased tissue selected from the group consisting of the head, body and other anatomy.