Retroviral vectors
AssigneeIP2Ipo Innovations Limited
InventorsDeborah R. Gill, Stephen C. Hyde
Life of this patent
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Abstract
This invention relates to retroviral gene transfer vectors, particularly lentiviral vectors, pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, comprising a promoter and a transgene; and methods of making the same. The present invention also relates to the use of said vectors in gene therapy, particularly for the treatment of respiratory tract diseases such as Cystic Fibrosis (CF).
Claims30
-33. (canceled)
A retroviral vector pseudotyped with hemagglutinin-neuraminidase (HN) and fusion (F) proteins from a respiratory paramyxovirus, which is obtainable by a method comprising obtaining codon-optimised gag-pol genes, and transfecting cells with one or more plasmids encoding the retroviral vector and the codon-optimised gag-pol genes, wherein the codon-optimised gag-pol genes comprise a nucleic acid sequence having at least 80% sequence identity to SEQ ID NO:1, wherein the retroviral vector comprises a promoter and a transgene.
Dependencies are inferred from the claim text.