Preparation method for drug linker conjugate
AssigneeMediLink Therapeutics (Suzhou) Co., Ltd.
InventorsShuai SONG, Jundong LI, Bin YAN, Xiaozhou ZHANG, Zizhen WANG, Jiaqiang CAI
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Abstract
The present invention provides a preparation method for a drug linker conjugate. The present invention further provides a preparation method for an intermediate or a salt thereof, and a use of an intermediate or a salt thereof. The raw materials involved in the preparation method of the present invention are easily obtained, the operation is simple, the purity of a product is high, and the present invention is suitable for high-volume synthesis.
Claims16
A preparation method for a compound of formula I or a salt thereof, comprising the following steps:
- c) reacting a compound of formula 6 or a salt thereof with a compound of formula 7 or a salt thereof to obtain a compound of formula 8 or a salt thereof,
- d) reacting the compound of formula 8 or the salt thereof to obtain a compound of formula 9 or a salt thereof,
- e) reacting the compound of formula 9 or the salt thereof with a compound of formula 10 to obtain a compound of formula I or a salt thereof,
- wherein
- R1 and R2 are each independently selected from C1-4 alkyl;
- R3 is selected from hydroxyl and halogen;
- PG1 is selected from an amino protecting group.
A compound of the following formulas or a salt thereof,
- wherein
- R1 and R2 are each independently selected from C1-4 alkyl;
- X is selected from halogen;
- PG1 is selected from an amino protecting group;
- the compound of formula 7 is not
Dependencies are inferred from the claim text.