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US 2025/0177513 A1Published application
Rabies g protein and uses thereof
AssigneeIcosavax, Inc.
InventorsANDREW FELDHAUS, DOUGLAS HOLTZMAN
Life of this patent
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Abstract
Provided are polypeptide comprising a rabies G protein ectodomain. The rabies G protein ectodomain may have a deletion of the fusion loop domain. Further provided are nanoparticle vaccines for rabies virus. Further provided are pharmaceutical compositions, methods of manufacturing, and methods of use, e.g., immunizing a subject to generate a protective immune response to rabies virus.
Claims56
A polypeptide, comprising a rabies G protein ectodomain, wherein the rabies G protein ectodomain comprises a deletion of a fusion loop domain of the rabies G protein ectodomain,
- wherein the deleted fusion loop domain is about residue 70 to about residue 200 of the rabies G protein ectodomain, numbered according to SEQ ID NO:
- 53;
- or
- wherein the deleted fusion loop domain is about residue 50 to about residue 180, about residue 70 to about residue 180, about residue 80 to about residue 180, about residue 90 to about residue 180, or about residue 100 to about residue 180;
- about residue 50 to about residue 190, about residue 70 to about residue 190, about residue 80 to about residue 190, about residue 90 to about residue 190, or about residue 100 to about residue 190;
- about residue 50 to about residue 200, about residue 70 to about residue 200, about residue 80 to about residue 200, about residue 90 to about residue 200, or about residue 100 to about residue 200;
- about residue 50 to about residue 210, about residue 70 to about residue 210, about residue 80 to about residue 210, about residue 90 to about residue 210, or about residue 100 to about residue 210;
- about residue 50 to about residue 220, about residue 70 to about residue 220, about residue 80 to about residue 220, about residue 90 to about residue 220, or about residue 100 to about residue 220 of the rabies G protein ectodomain, numbered according to SEQ ID NO:
- 53.
6 more elements
Dependencies are inferred from the claim text.