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US 2025/0177324 A1Published application
Aminoketone compound, and preparation method therefor and use thereof
AssigneeShanghai Zhigen Pharmaceutical & Technology Co., Ltd.
InventorsTao XUE, Yilang CHEN
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Abstract
A new aminoketone compound, and a preparation method therefor and the use thereof are provided. Specifically, the compound has a structure as shown in formula (I), wherein the definition of each group and substituent are as described in the description. A preparation method for the compound is provided. The compound can be used to treat depression.
Claims10
A compound of formula (I), or a tautomer, an enantiomer, a diastereoisomer, a racemate, or a mixture thereof, or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is selected from the group consisting of deuterium and C1-C6 alkyl;
- R2, R3 and R4 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl and —(C═O)—C1-C6 alkyl;
- R5, R6, R7, R8 and R9 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, halogenated C1-C6 alkyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, halogen, nitro and cyano;
- and at least 2 of R5, R6, R7, R8 and R9 are hydrogen;
- the stereo configuration of the α-position or β-position carbon atom is each independently selected from the group consisting of:
- R, S and (R, S).
4 more elements
Dependencies are inferred from the claim text.