Production of psychedelic compounds
OwnerJan BURIANinventor
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Abstract
This disclosure relates to recombinant microbes, systems, and methods useful in the production of psilocybin and dimethyltryptarme (DMT). The disclosure relates to modifications and optimizations to genes and enzymes directly involved in the psilocybin and DMT pathway for the production of psilocybin and DMT in a host cell. The disclosure also relates to modifications and optimizations to genes and enzymes in the host cell and medium for psilocybin and DMT production in E. coli. The present disclosure also relates to a semi-synthetic method of producing psilocybin.
Claims155
A recombinant microbial cell comprising a biosynthetic pathway for producing psilocybin, or intermediates thereof, the microbial cell comprising a heterologous nucleic acid encoding one or more psilocybin production genes.
A nucleic acid molecule comprising a sequence having at least 70%, at least 80%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to any one of SEQ ID NOs:
- 1 to 7, 13 to 18, 20 to 26, and 32 to 37, or a combination thereof.
A recombinant microbial cell comprising a biosynthetic pathway for producing dimethyltryptamine (DMT), or intermediates thereof, the microbial cell comprising a heterologous nucleic acid encoding one or more DMT production genes.
A nucleic acid molecule comprising a sequence having at least 70%, at least 80%, at least 90%, at least 95%, at least 96%, at least 97%, at least 98%, at least 99%, or 100% sequence identity to any one of SEQ ID NOs:
- 1 to 3, 8 to 13, 20 to 22, and 27 to 32, or a combination thereof.
Dependencies are inferred from the claim text.