Coral bioinks
AssigneesCellink Bioprinting AB, Zoan NuáIl Teoranta
InventorsAdel Itedal Namro REDWAN, Volodymyr KUZMENKO, Elin Astrid Margareta PERNEVIK, Stephen WANN, Martin JOHNSON, James MARTIN
Life of this patent
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Abstract
A bioink is described. The bioink comprises coral particles and biocompatible polymer, wherein the concentration of coral particles in the bioink is 25 to 85 weight % of the total weight of the bioink.
Claims25
A bioink comprising coral particles and biocompatible polymer, wherein the concentration of coral particles in the bioink is 25 to 85 weight % of the total weight of the bioink.
A bioink comprising coral particles, biocompatible polymer and biological cells and/or biologically active molecules, wherein the concentration of coral particles in the bioink is 1 to 25 weight % of the total weight of the bioink.
A bioink as claimed in claim 24, wherein the crosslinkable polymer is selected from alginate, methacrylated alginate, methacrylated collagen and methacrylated gelatin.
A method of producing a coral scaffold, said method comprising
- producing a first portion of the coral scaffold by extruding a first bioink comprising coral particles and a biocompatible polymer, wherein the concentration of coral particles in the first bioink is 25 to 80 weight % of the total weight of the first bioink;
- and/or producing a second portion of the coral scaffold by extruding a second bioink comprising coral particles, a biocompatible polymer and biological cells and/or biologically active molecules, wherein the concentration of coral particles in the second bioink is 1 to 25 weight % of the total weight of the second bioink;
- said method further comprising crosslinking the biocompatible polymer in the first portion and/or second portion of the scaffold.
A coral scaffold comprising a first portion that comprises coral and a biocompatible polymer, wherein the concentration of coral in the first portion is 25 to 80 weight % of the total weight of the first portion;
- and/or
- a second portion that comprises coral, a biocompatible polymer and biological cells and/or biologically active molecules, wherein the concentration of coral in the second portion is 1 to 25 weight % of the second portion.
A method of growing coral, said method comprising
- extruding a bioink comprising coral particles and biocompatible polymer to form a coral scaffold precursor,
- crosslinking the coral scaffold precursor to form the coral scaffold;
- positioning the coral scaffold in a growth medium, and
- culturing coral growth over the coral scaffold.
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Dependencies are inferred from the claim text.