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AssigneeUniversität Hamburg
InventorsFranziska ESMEK, Irene FERNANDEZ-CUESTA
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A nanofluidic analysis device allowing for spontaneous flow of molecules and method for the analysis of DNA molecules, the device comprising a detection nanochannel, a supply channel in fluid communication with an inlet for the detection nanochannel and a discharge channel in fluid communication with an outlet for the detection nanochannel, so that a fluid comprising DNA molecules introduced into the supply channel may flow along a flow direction through the supply channel, via the inlet into the detection nanochannel, through the detection nanochannel, and out of the outlet into the discharge channel, wherein a laser detector system is provided for analyzing the DNA molecules in the detection nanochannel, wherein both a width and a depth of the inlet and thereby a cross section of the inlet decrease along the flow direction and wherein both a width and a depth of the outlet and thereby a cross section of the outlet increase along the flow direction, wherein the detection nanochannel has a length of not more than 35 μm.
A nanofluidic analysis device for the analysis of DNA molecules, comprising a detection nanochannel, a supply channel in fluid communication with an inlet for the detection nanochannel and a discharge channel in fluid communication with an outlet for the detection nanochannel, so that a fluid comprising DNA molecules introduced into the supply channel may flow along a flow direction through the supply channel, via the inlet into the detection nanochannel, through the detection nanochannel, and out of the outlet out of the detection nanochannel into the discharge channel, wherein a laser detector system is provided for analyzing the DNA molecules in the detection nanochannel, wherein both a width and a depth of the inlet and thereby a cross section of the inlet decrease along the flow direction and wherein both a width and a depth of the outlet and thereby a cross section of the outlet increase along the flow direction, wherein the detection nanochannel has a length of not more than 35 μm.
A method for the analysis of DNA molecules via a nanofluidic analysis device, wherein a fluid comprising DNA molecules is introduced into a supply channel of the nanofluidic analysis device, the fluid spontaneously flowing along a flow direction through the supply channel, into a detection nanochannel of the nanofluidic analysis device via an inlet, both a width and a depth of the inlet and thereby a cross section of the inlet decreasing along the flow direction, the detection nanochannel having a length of not more than 35 μm, the fluid having entered the detection nanochannel spontaneously flowing along the flow direction through the detection nanochannel, wherein the DNA molecules inside the detection nanochannel are analyzed via a laser detector system, the fluid further spontaneously leaving the detection nanochannel along the flow direction through an outlet into a discharge channel, both a width and a depth of the outlet and thereby a cross section of the outlet increasing along the flow direction.
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