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US 2025/0170280 A1Published application
Liposomal nanocarrier delivery system for targeting active cd44 molecule, preparation method therefor, and uses thereof
AssigneeBeijing Inno Medicine Co., Ltd.
InventorsQian Ma, Jiefang Sun
Life of this patent
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Abstract
A liposomal nanocarrier delivery system for targeting an active CD44 molecule, preparation method therefor, and uses thereof. The surface of the liposome is partially modified by a targeting ligand, wherein the targeting ligand is a ligand that can be specifically combined with the active CD44 molecule. The liposomal nanocarrier delivery system can be used for diagnosing, preventing, and treating vulnerable plaque or diseases related to vulnerable plaque.
Claims24
A liposome nanocarrier delivery system, wherein the surface of the liposome nanocarrier is partially modified by a targeting ligand;
- wherein the targeting ligand is selected from the group consisting of GAG, collagen, laminin, fibronectin, selectin, osteopontin (OPN), monoclonal antibodies HI44a, HI313, A3D8, H90 and IM7, a hyaluronic acid, a pharmaceutically acceptable salt of the hyaluronic acid, and an alkyl (alkyl containing 1 to 6 carbon atoms) ester of the hyaluronic acid;
- and the liposome nanocarrier is loaded within vesicles with a tracer;
- wherein the liposome nanocarrier is selected from the group consisting of small unilamellar vesicles, large unilamellar vesicles and multilamellar vesicles.
Dependencies are inferred from the claim text.