Compositions and methods for therapeutic delivery
AssigneeGenVivo, Inc.
InventorsMakoto Sato, Alexander T. Cunha, Cecilia Roh, Robert G. JOHNSON, JR.
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Abstract
Described herein are compositions and methods for therapeutic delivery using an engineered viral vector. The engineered viral vector provided herein can improve therapeutic delivery, increase targeting efficiency, and decrease off-targeting or adverse effects.
Claims36
An engineered viral vector comprising a modified envelope protein, wherein the modified envelope protein comprises:
- a) at least one targeting moiety, and
- b) at least one modification in a wild-type protein sequence (SEQ ID NO:
- 1);
- wherein the modified envelope protein increases transduction efficiency or specificity of the engineered viral vector to a target cell relative to a viral vector without the modified envelope protein.
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Dependencies are inferred from the claim text.