Novel b0at1 inhibitor

A compound represented by the formula (I′):

• wherein
• R1′ is a C2-6 alkyl group, a halo C1-6 alkyl group, a C3-6 cycloalkyl group, a C2-6 alkoxy group, a halo C2-6 alkoxy group, a C3-6 cycloalkyloxy group, a C3-6 cycloalkyl-C1-4 alkoxy group, a C2-6 alkylsulfanyl group, a halo C1-6 alkylsulfanyl group, a C3-6 cycloalkylsulfanyl group, a pentafluorosulfanyl group, a C6-14 aryl group optionally substituted by a halogen atom, or a 5- or 6-membered nitrogen-containing aromatic heterocyclic group optionally substituted by a halogen atom or a C1-6 alkyl group;
• X′ in the number of n′ are each independently a fluorine atom or a chlorine atom;
• n′ is an integer of 0 to 2;
• and
• R2″ is a C1-4 alkyl group substituted by substituent(s) selected from substituent group a, and
• R3′ is a C1-4 alkyl group optionally substituted by substituent(s) selected from substituent group a or a C3-6 cycloalkyl group optionally substituted by substituent(s) selected from substituent group b, or
• R2′ and R3′ are bonded to each other to form, together with a nitrogen atom bonded thereto, a nitrogen-containing non-aromatic heterocyclic group optionally substituted by substituent(s) selected from substituent group b
• (substituent group a):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group;
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• di-C1-6 alkylamino group;
• C3-8 cycloalkyl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group c;
• and
• non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group b
• (substituent group b):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• oxo group;
• thioxo group;
• amino group optionally substituted by 1 or 2 substituents selected from the group consisting of a C1-6 alkyl group, a C1-6 alkyl-carbonyl group, and a C1-6 alkoxy-carbonyl group;
• C1-6 alkyl group optionally substituted by substituent(s) selected from the group consisting of a halogen atom, a hydroxy group, and a C1-6 alkoxy group;
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group optionally substituted by halogen atom(s);
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• aminosulfonyl group substituted by one substituent selected from the group consisting of a C1-6 alkyl group, a C3-8 cycloalkyl group, and a non-aromatic heterocyclic group, each of which is optionally substituted by 1 to 3 substituents selected from substituent group c;
• trisubstituted silyl group;
• trisubstituted silyloxy group;
• C3-8 cycloalkyl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• and
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group c
• (substituent group c):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• amino group optionally substituted by 1 or 2 substituents selected from the group consisting of a C1-6 alkyl group and a C1-6 alkoxy-carbonyl group;
• C1-6 alkyl group optionally substituted by halogen atom(s);
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group;
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a C1-6 alkyl group, and a C1-6 alkoxy group;
• and
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a C1-6 alkyl group, and a C1-6 alkoxy group.]
• or a salt thereof, excluding compounds represented by the following formulas:

A compound represented by the formula (I″):

• wherein
• R1″ is a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C3-8 cycloalkyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted C3-8 cycloalkyloxy group, an optionally substituted C1-6 alkylsulfanyl group, an optionally substituted C3-8 cycloalkylsulfanyl group, a pentafluorosulfanyl group, an optionally substituted C6-14 aryl group, or an optionally substituted 5- or 6-membered aromatic heterocyclic group;
• X″ in the number of n″ are each independently a fluorine atom or a chlorine atom;
• n″ is an integer of 0 to 2;
• and
• R2″ is a C1-4 alkyl group substituted by a group selected from the group consisting of
• (i) a 5- or 6-membered monocyclic nitrogen-containing aromatic heterocyclic group optionally substituted by substituent(s) selected from substituent group c, and
• (ii) a 5- or 6-membered monocyclic nitrogen-containing non-aromatic heterocyclic group optionally substituted by substituent(s) selected from substituent group b, and
• optionally further substituted by substituent(s) selected from substituent group a, and R3″ is a C1-4 alkyl group substituted by substituent(s) selected from substituent group a, or
• R2″ and R3″ are bonded to each other to form, together with a nitrogen atom bonded thereto, a fused nitrogen-containing non-aromatic heterocyclic group (excluding a tetrahydroquinolyl group and a tetrahydroisoquinolyl group) optionally substituted by substituent(s) selected from substituent group b
• (substituent group a):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group;
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• di-C1-6 alkylamino group;
• C3-8 cycloalkyl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group c;
• and
• non-aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group b
• (substituent group b):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• oxo group;
• thioxo group;
• amino group optionally substituted by 1 or 2 substituents selected from the group consisting of a C1-6 alkyl group, a C1-6 alkyl-carbonyl group, and a C1-6 alkoxy-carbonyl group;
• C1-6 alkyl group optionally substituted by substituent(s) selected from the group consisting of a halogen atom, a hydroxy group, and a C1-6 alkoxy group;
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group optionally substituted by halogen atom(s);
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• aminosulfonyl group substituted by one substituent selected from the group consisting of a C1-6 alkyl group, a C3-8 cycloalkyl group, and a non-aromatic heterocyclic group, each of which is optionally substituted by 1 to 3 substituents selected from substituent group c;
• trisubstituted silyl group;
• trisubstituted silyloxy group;
• C3-8 cycloalkyl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from substituent group c;
• and
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from substituent group c
• (substituent group c):
• halogen atom;
• hydroxy group;
• cyano group;
• carboxy group;
• amino group optionally substituted by 1 or 2 substituents selected from the group consisting of a C1-6 alkyl group and a C1-6 alkoxy-carbonyl group;
• C1-6 alkyl group optionally substituted by halogen atom(s);
• C1-6 alkoxy group optionally substituted by halogen atom(s);
• C1-6 alkylsulfonyl group optionally substituted by halogen atom(s);
• C1-6 alkyl-carbonyl group;
• C1-6 alkoxy-carbonyl group;
• carbamoyl group optionally substituted by 1 or 2 C1-6 alkyl groups optionally substituted by substituent(s) selected from the group consisting of a hydroxy group, a di-C1-6 alkylamino group, and a C1-6 alkoxy group;
• C6-14 aryl group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a C1-6 alkyl group, and a C1-6 alkoxy group;
• and
• nitrogen-containing aromatic heterocyclic group optionally substituted by 1 to 3 substituents selected from the group consisting of a halogen atom, a C1-6 alkyl group, and a C1-6 alkoxy group,
• or a salt thereof.