Molecular jackhammer for mechanical destruction of cellular structure
AssigneesWilliam Marsh Rice University, Nanorobotics, LTD
InventorsCiceron AYALA-OROZCO, James M. TOUR, Gang LI, Bowen LI
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Abstract
In one aspect, the present disclosure describes methods which may be used to disrupt cellular membranes. These compounds may generate a vibronic-driven action when exposed to a sufficient energy source and that action may be used to disrupt the membrane of a cell or other organism. Also described are compounds and uses thereof.
Claims52
A method of disrupting a membrane comprising:
- (A) contacting the membrane with a compound, wherein the compound is capable of generating a vibronic-driven action and optionally further comprising a targeting moiety;
- and
- (B) exposing the compound to an energy source sufficient to generate the vibronic-driven action, wherein the vibronic-driven action is sufficient to disrupt the membrane.
Use of a compound for disrupting a membrane comprising:
- (A) contacting the membrane with the compound, wherein the compound is capable of generating a vibronic-driven action and optionally further comprising a targeting moiety;
- and
- (B) exposing the compound to an energy source sufficient to generate the vibronic-driven action, wherein the vibronic-driven action is sufficient to disrupt the membrane.
A composition for use in the disrupting of a membrane comprising a compound, wherein the compound is capable of generating a vibronic-driven action and optionally further comprising a targeting moiety, provided that when the compound is exposed to an energy source sufficient to generate the vibronic-driven action, then the vibronic-driven action is sufficient to disrupt the membrane.
A method of treating a disease or disorder in a patient comprising:
- (A) contacting the cell membrane of at least one cell of said patient with a compound, wherein the compound capable of generating a vibronic-driven action and optionally further comprising a cell targeting moiety;
- and
- (B) exposing the compound to an energy source sufficient to generate a vibronic-driven action, wherein the vibronic-driven action is sufficient to disrupt the cell membrane of at least one cell of said patient.
A method of opening a cell membrane comprising:
- (A) contacting the cell membrane with a compound, wherein the compound capable of generating a vibronic-driven action and optionally further comprising a cell targeting moiety;
- and
- (B) exposing the compound to an energy source sufficient to generate a vibronic-driven action, wherein the vibronic-driven action is sufficient to open the cell membrane.
A method of reducing the amount of adipose tissue in a patient comprising contracting the adipose tissue with a compound, wherein the compound capable of generating a vibronic-driven action and optionally further comprising a cell targeting moiety;
- and
- exposing the compound to an energy source sufficient to generate a vibronic-driven action, wherein the vibronic-driven action is sufficient to reduce the adipose tissue.
A method of disrupting a cellular component comprising:
- (A) contacting the cellular component with a compound, wherein the compound is capable of generating a vibronic-driven action and optionally further comprising a targeting moiety;
- and
- (B) exposing the compound to an energy source sufficient to generate the vibronic-driven action, wherein the vibronic-driven action is sufficient to disrupt the cellular component.
A compound of the formula:
- wherein:
- R1 and R1′ are each independently alkyl(C≤8), substituted alkyl(C≤8), or a group of the formula:
- -A-NRaRa′Ra″
- wherein:
- A is an alkanediyl(C≤12) or substituted alkanediyl(C≤12);
- Ra and Ra′ are each independently hydrogen or alkyl(C≤8);
- and
- Ra″ is absent, hydrogen, or alkyl(C≤8);
- provided at least one of R1 and R1′ is a group of the formula:
- -A-NRaRa′Ra″
- R2, R2′, R3, and R3′ are each independently hydrogen, alkyl(C≤8), or substituted alkyl(C≤8);
- R4 and R4′ are each independently hydrogen, alkyl(C≤8), substituted alkyl(C≤8), or R4 and R4′ are taken together as a cycloalkyl group;
- R5 is hydrogen, halo, carboxy, alkyl(C≤8), substituted alkyl(C≤8), or —C(O)ORb, wherein Rb is alkyl(C≤6) or substituted alkyl(C≤6);
- R6 is hydrogen, amino, halo, hydroxy, or alkyl(C≤12), alkoxy(C≤12), alkylamino(C≤8), dialkylamino(C≤8), acyl(C≤8), acyl(C≤8), acyl(C≤8), or a substituted version thereof;
- m and n are each 0, 1, 2, or 3;
- x and y are each independently 0, 1, 2, 3, 4, or 5;
- X is a monovalent anion;
- and
- each of the rings is optionally present as either an aromatic or aliphatic ring.
A method of disrupting a cell membrane comprising contacting the cell membrane with a compound of formula:
- and exposing the membrane to an energy source capable of generating vibronic-driven action.
Dependencies are inferred from the claim text.