Methods and Compositions For Measuring Serum Analyte Levels From Biological Matrices

A method for treating a disease or condition in a subject in need thereof, comprising:

• a. determining a level of an analyte in a serum of the patient, comprising:
• i) perturbing a soft tissue in a mouth or other cavity of the patient;
• ii) collecting a sample of fluid from the mouth or other cavity of the patient;
• and
• iii) measuring the level of the analyte in the sample of fluid from the mouth or other cavity of the patient,
• wherein measuring the level of the analyte in the sample of fluid from the mouth or other cavity of the patient determines the level of the analyte in the serum of the patient;
• and
• b. administering a drug to the subject.

A method for treating a disease or condition in a subject in need thereof, comprising:

• a. determining a level of an analyte in a serum of the patient, comprising:
• i) perturbing a soft tissue in a mouth or other cavity of the patient;
• ii) collecting a sample of fluid from the mouth or other cavity of the patient;
• and
• iii) measuring the level of the analyte in the sample of fluid from the mouth or other cavity of the patient,
• wherein measuring the level of the analyte in the sample of fluid from the mouth or other cavity of the patient determines the level of the analyte in the serum of the patient;
• and
• b. administering an anti-drug antibody or antigen-binding fragment thereof to the subject.