# US 2025/0164355 A1 · Apparatuses and methods for segregating tissue samples for multiple diagnostic modalities > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0164355 A1 - Document ID: US20250164355A1 - Status: Published application - Kind: A1 - Application number: 18/403,550 - Filed: 2024-01-03 - Published: 2025-05-22 - Earliest claimed: 2023-11-20 - Assignees: Corramedical, Inc. - Applicants: Corramedical, Inc. - Inventors: Alexander ARROW; Wilfrido MOJICA - Web page: https://patentgrep.com/patent/US20250164355A1 ## CPC - G01N 1/286: {involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising (microtomes G01N1/06; pulverising in general B02C; mixing in general B01F)} - A61B 10/0096: {Casings for storing test samples (A61B10/0038, A61B10/0045 take precedence; preservation of living parts of the human or animal body A01N1/10; containers for retaining a material to be analysed B01L3/50; containers for enzymology or microbiology C12M1/16; swab-sampler being part of enzymology or microbiology container C12M1/30)} - A61B 10/0275: {with sample notch, e.g. on the side of inner stylet} - G01N 1/4077: {by other techniques involving separation of suspended solids} - A61B 10/0283: {with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe (A61B10/025, A61B10/0266 take precedence)} - B01L 2200/16: Reagents, handling or storing thereof - B01L 2300/042: Caps; Plugs - B01L 2300/0681: Filter - B01L 2300/0832: cylindrical, tube shaped - G01N 2001/2866: {Grinding or homogeneising} - G01N 2001/4088: {filtration} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ## Abstract Apparatuses and methods for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy are disclosed herein. In an embodiment, a biopsy container apparatus includes a sample collection container, a basket sieve, and a buffer container. The sample collection container includes a reagent chamber. The basket sieve is configured for removable attachment at least partially within the sample collection container and includes a sieve surface configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy. The buffer container is configured for removable attachment to the sample collection container and includes a buffer chamber. ## Claims ### Claim 1 A biopsy container apparatus for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy, the biopsy container apparatus comprising: a sample collection container including a reagent chamber; a basket sieve configured for removable attachment at least partially within the sample collection container, the basket sieve including a sieve surface configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy; and a removable container configured for removable attachment to the sample collection container, the removable container including a chamber. ### Claim 2 (depends on 1) The biopsy container apparatus of claim 1, wherein the removable container includes a funnel portion configured to guide the solid tissue and the D-cells from the biopsy into the buffer chamber. ### Claim 3 (depends on 2) The biopsy container apparatus of claim 2, wherein the removable container is configured for attachment to the sample collection container with the chamber at least partly located within the sample collection container, and with the funnel portion at least partly located outside of the sample collection container. ### Claim 4 (depends on 1) The biopsy container apparatus of claim 1, wherein the sample collection container includes a rim configured to suspend the basket sieve within the sample collection container above the reagent chamber. ### Claim 5 (depends on 1) The biopsy container apparatus of claim 1, wherein the removable container includes an inner surface with a first attachment mechanism, the sample collection container includes an outer surface with a second attachment mechanism, and the removable container is removably attached to the sample collection container by cooperation between the first attachment mechanism and the second attachment mechanism. ### Claim 6 (depends on 5) The biopsy container apparatus of claim 5, wherein the first attachment mechanism and the second attachment mechanism include corresponding threads enabling the removable container to be screwed onto the sample collection container. ### Claim 7 (depends on 1) The biopsy container apparatus of claim 1, comprising a lid that fits both the sample collection container and the removable container. ### Claim 8 (depends on 1) The biopsy container apparatus of claim 1, wherein the sample collection container is pre-filled with a reagent in the reagent chamber, and the buffer container is pre-filled with a solution in the chamber. ### Claim 9 (depends on 8) The biopsy container apparatus of claim 8, wherein the sample collection container includes between 1 and 2 mL of reagent, and the removable container includes between 1 and 2 mL of solution. ### Claim 10 (depends on 8) The biopsy container apparatus of claim 8, wherein the sample collection container includes a first amount of reagent, and the removable container includes a second amount of solution that is approximately equal in volume to the first amount of reagent. ### Claim 11 (depends on 8) The biopsy container apparatus of claim 8, wherein the solution includes a saline solution. ### Claim 12 (depends on 1) The biopsy container apparatus of claim 1, wherein the removable container includes a skirt configured to removably attach the removable container to the sample collection container. ### Claim 13 A biopsy container apparatus for recovering solid tissue and dislodged cells (“D-cells”) from a biopsy, the biopsy container apparatus comprising: a sample collection container including a reagent; a basket sieve configured for removable attachment at least partially within the sample collection container, the basket sieve including a sieve surface configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy; and a removable container configured for removable attachment to the sample collection container, the removable container including a solution. ### Claim 14 (depends on 13) The biopsy container apparatus of claim 13, wherein the basket sieve is located between the removable container and the sample collection container when the chamber is attached to the sample collection container. ### Claim 15 A method of recovering solid tissue and dislodged cells (“D-cells”) from a biopsy using a biopsy container apparatus including a removable container, a basket sieve and a sample collection container, the method comprising: depositing the solid tissue and the D-cells from the biopsy into a solution within the removable container; removing the removable container from the basket sieve and the sample collection container; pouring the solid tissue, the D-cells and the solution into the basket sieve while the basket sieve is located within the sample collection container; removing the basket sieve with the solid tissue from the sample collection container; placing the basket sieve with the solid tissue into a sealed container for tissue processing; and sealing a mixture including the D-cells, the solution and the reagent for diagnostic testing. ### Claim 16 (depends on 15) The method of claim 15, comprising depositing the solid tissue and the D-cells from a core needle into the chamber. ### Claim 17 (depends on 15) The method of claim 15, wherein sealing a mixture including the D-cells, the solution and the reagent includes sealing the mixture within the sample collection container. ### Claim 18 (depends on 15) The method of claim 15, comprising receiving the biopsy container apparatus with the removable container, the basket sieve and the sample collection container attached together. ### Claim 19 (depends on 18) The method of claim 18, comprising receiving the biopsy container apparatus with the sample collection container pre-filled with a reagent, the basket sieve located at least partially within the sample collection container, and the removable container pre-filled with a solution and located at least partially within the sample collection container. ### Claim 20 (depends on 15) The method of claim 15, comprising removing a lid from the removable container before depositing the solid tissue and the D-cells from the biopsy into the removable container, and wherein sealing the mixture including the D-cells, the solution and the reagent for diagnostic testing includes sealing the D-cells, the solution and the reagent within the sample collection container using the lid.