Method for differentiating hematopoietic stem/progenitor cells into nk cells
AssigneeHemacell Biotechnology Inc.
InventorChen WU
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Abstract
The present invention relates to a method for inducing proliferation and/or differentiation of hematopoietic stem/progenitor cells, the method comprising activating the y-aminobutyric acid pathway of hematopoietic stem/progenitor cells. The present invention also provides a culture medium for inducing proliferation and/or differentiation of hematopoietic stem/progenitor cells into NK cells and use thereof.
Claims29
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A method for inducing proliferation and/or differentiation of hematopoietic stem/progenitor cells into NK cells, comprising administering a GABA pathway activator to the hematopoietic stem/progenitor cells, wherein the concentration of the GABA pathway activator is about 0.1-1000 mM.
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A medium kit comprising an initial differentiation medium and an NK differentiation medium, wherein the initial differentiation medium comprises a GABA pathway activator.
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Dependencies are inferred from the claim text.