An innervated cellular composite
AssigneeAlcyomics LTD
InventorsAnne DICKINSON, Matthew FREER
Life of this patent
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Abstract
The present invention relates to a cellular composite, which advantageously may be innervated. The invention also relates to methods of making said cellular composite, uses of said cellular composite, and screening methods utilising said cellular composite and uses of the cellular composite.
Claims23
A cellular composite comprising:
- a keratinocyte cell layer;
- a 3D (three dimensional) cell growth material;
- and
- a neuronal cell layer,
- wherein the 3D cell growth material is located between the keratinocyte cell layer and the neuronal cell layer, and
- wherein the 3D cell growth material comprises a mixed population of fibroblast cells and Schwann cells.
(canceled)
A method of making a cellular composite comprising a keratinocyte cell layer, a 3D (three dimensional) cell growth material, and a neuronal cell layer, wherein the 3D cell growth material is located between the keratinocyte cell layer and the neuronal cell layer, and wherein the 3D cell growth material comprises a mixed population of fibroblast cells and Schwann cells, wherein the method comprises the steps of:
- a) seeding fibroblast cells and Schwann cells into the 3D cell growth material;
- b) seeding neuronal cells on a first outer surface of the 3D cell growth material;
- and
- c) seeding keratinocyte cells on a second outer surface of the 3D cell growth material,
- wherein the first outer surface and the second outer surface are substantially parallel to one another and the 3D cell growth material is located between the first outer surface and the second outer surface.
21-34. (canceled)
36-46. (canceled)
Dependencies are inferred from the claim text.