Compounds and compositions for neurodegenerative diseases
AssigneeUniversidade Nov A De Lisboa
InventorsMaria Cláudia GODINHO FERREIRA DIAS NUNES DOS SANTOS, Rafael José MERCA SARAIVA MONTEIRO CARECHO, Diogo Miguel JOSÉ CARREGOSA
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Abstract
The present disclosure relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of a neurodegenerative disease. Furthermore, the present invention relates to the non-therapeutic use of said compounds for maintaining and/or improving neurological and/or brain function, preferably as a food or nutraceutical composition.
Claims31
A compound of formula (I) or a pharmaceutically acceptable salt thereof the compound comprising:
- wherein:
- [R], A and B are independently selected from each other,
- [R]n is one radical R if n is 1 or represents n radicals R attached to different positions of the basic ring if n is more than 1, and wherein each R is independently selected from the group consisting of:
- OH, CH3, CH2OH, OCH3, OCH2CH3, OSO3H, OSO3CH3, OSO3CH2CH3, F, Cl, Br, and I, wherein n represents the number of radicals in the compound and is 1, 2 or 3,
- A is a spacer selected from the group consisting of CH2, CH(OH), CH(CH3), CH2CH2, CH(CH3)CH2, CH2CH(CH3), CH(OH)CH2, CH2CH(OH), (Z)CH═CH, (E)CH═CH, and C(═O)NHCH2, wherein m represents the number of spacers in the compound and is 0 or 1,
- B is C(═O)OH or OSO3H,
- wherein at least 1, 2 or 3 radicals R are OH, and
- wherein if B is C(═O)OH, there is an R in position 5, wherein the R in position 5 is OSO3H and m=0.
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Dependencies are inferred from the claim text.