# US 2025/0155463 A1 · Dual-head magnetic liquid handler robot for high throughput antibody purification apparatus, system and method > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0155463 A1 - Document ID: US20250155463A1 - Status: Published application - Kind: A1 - Application number: 18/949,983 - Filed: 2024-11-15 - Published: 2025-05-15 - Earliest claimed: 2023-11-15 - Assignees: Dynamic Devices LLC - Applicants: Dynamic Devices LLC - Inventors: Jean-Marc Haab; Kelly Kreitlow - Web page: https://patentgrep.com/patent/US20250155463A1 ## CPC - G01N 35/1009: {Characterised by arrangements for controlling the aspiration or dispense of liquids} - B01L 3/5085: {for multiple samples, e.g. microtitration plates} - G01N 1/34: Purifying; Cleaning {(processes or apparatus for extracting or separating nucleic acids from biological samples C12N15/1003)} - G01N 35/0099: {comprising robots or similar manipulators (robots per se B25J)} - G01N 35/1074: {arranged in a two-dimensional array} - B01L 2300/0829: Multi-well plates; Microtitration plates - G01N 2035/00564: {Handling or washing solid phase elements, e.g. beads} - G01N 2035/103: {using disposable tips} - G01N 2035/1076: {plurality or independently movable heads} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE ## Abstract An apparatus, system, process, and method for purifying, handling and otherwise processing engineered biologics molecules which may comprise plate-based antibody purification processes is disclosed. The resultant purified molecules may be further processed optimized, and/or used in other manufacturing processes and/or manufactured products. In one embodiment the system and method employed for the processing and purifying of antibodies comprises a high speed, high throughput, dual-head magnetic liquid handler robot and related systems which efficiently produces end product at high yields. In certain embodiments, the system is fully automated providing for cost-effective and efficient means for purifying, handling and otherwise processing engineered biologics molecules such as the purification of plate-based antibodies in commercially advantageous quantities. The resultant purified molecules may be further processed optimized, and/or used in other manufacturing processes and/or manufactured products. Also disclosed is an embodiment of the invention which utilizes a magnetic liquid handler robot and related systems comprising a single robotic arm which automatically interchanges tooling heads and which efficiently produces end product at high yields. ## Claims ### Claim 1 An apparatus for handling, purifying, and otherwise processing engineered biologics molecules comprising: liquid handler assembly; one or more interchangeable tooling heads adapted to engage and disengage with said liquid handler assembly; a positive pressure manifold and adapter adapted to engage with said liquid handler assembly; a sample plate having a plurality of individual wells to store, process and transport the engineered biologics molecules samples being processed by said liquid handler assembly; and a computerized control system which generates commands to said apparatus to sequentially execute the handling, purifying and otherwise processing said engineered biologics molecules. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein said engineered biologics molecules are antibodies. ### Claim 3 (depends on 1) The apparatus of claim 1, wherein said liquid handler assembly comprises dual robotic arms adapted to engage and disengage said interchangeable tooling heads. ### Claim 4 (depends on 1) The apparatus of claim 1, wherein said liquid handler assembly comprises dual robotic arms adapted to engage and disengage said positive pressure manifold and adapter. ### Claim 5 (depends on 1) The apparatus of claim 1, wherein said liquid handler assembly comprises a single robotic arm adapted to engage and disengage said interchangeable tooling heads. ### Claim 6 (depends on 1) The apparatus of claim 1, wherein said liquid handler assembly comprises a single robotic arm adapted to engage and disengage said positive pressure manifold and adapter. ### Claim 7 (depends on 1) The apparatus of claim 1, wherein said apparatus processes said biologics molecules in less than about two minutes on average. ### Claim 8 (depends on 1) The apparatus of claim 1, wherein said sample plate comprises six wells per plate. ### Claim 9 (depends on 1) The apparatus of claim 1, wherein said sample plate comprises twenty-four wells per plate. ### Claim 10 (depends on 1) The apparatus of claim 1, wherein said sample plate comprises ninety-six wells per plate. ### Claim 11 A positive pressure adapter comprising: a support plate having openings therethrough, wherein said openings are capable of accommodating one or more pipette tips; and a gasket adjacent to said support plate, said gasket having openings therethrough, wherein said openings are capable of accommodating one or more pipette tips. ### Claim 12 (depends on 11) The positive pressure adapter of claim 11, wherein said support plate comprises an ABS plastic. ### Claim 13 (depends on 11) The positive pressure adapter of claim 11, wherein said gasket comprises silicone. ### Claim 14 (depends on 11) The positive pressure adapter of claim 11, wherein said gasket is adhered to said support plate. ### Claim 15 (depends on 11) The positive pressure adapter of claim 11, further comprising an array of pipette tips inserted into said openings of said support plate and said gasket. ### Claim 16 (depends on 11) The positive pressure adapter of claim 11, further comprising a positive pressure manifold engaged with said positive pressure adapter to generate a positive pressure in a pipette tip inserted into said openings of said support plate and said gasket.