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US 2025/0154540 A1Published application
Novel variant of stress protein and method for preparing l-aromatic amino acid using the same
AssigneeDaesang Corporation
InventorsHyun Young KIM, Cheol Min YANG, Won Joo SHIN, Yong Soo KIM, Young JO, II
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Abstract
The present invention relates to a novel stress protein variant and a method of producing an L-aromatic amino acid using the same. The stress protein variant is obtained by substituting one or more amino acids in the amino acid sequence constituting glutathione reductase or stress protein B to change the activity of the protein, and a recombinant microorganism comprising the variant is capable of efficiently producing an L-aromatic amino acid.
Claims12
A variant selected from among:
- a glutathione reductase variant consisting of the amino acid sequence of SEQ ID NO:
- 1 in which threonine at position 74 in the amino acid sequence of SEQ ID NO:
- 3 is substituted with isoleucine;
- and
- a stress protein B variant consisting of the amino acid sequence of SEQ ID NO:
- 5 in which glutamine at position 42 in the amino acid sequence of SEQ ID NO:
- 7 is substituted with a stop codon.
4 more elements
Dependencies are inferred from the claim text.