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US 2025/0154444 A1Published application
System and method for aseptic sampling and fluid addition
AssigneeGlobal Life Sciences Solutions USA LLC
InventorsMARK ROBERT TIMMINS, MATTHEW SHERMAN, YASSER S. ALI, MARC PICARDO, KEITH BENOIT
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Abstract
A sampling system includes a graduated sampling chamber configured for fluid connection to a sample source, a pump device configured for fluid connection with the sampling chamber, and a sterile air filter intermediate the pump device and the sampling chamber, wherein the pump device is selectively actuatable to draw a volume of fluid from the sample source into the sampling chamber.
Claims8
A method for sampling, comprising the steps of:
- connecting a sampling chamber to a sample source;
- actuating a pump to draw a volume of fluid from the sample source through a valve, and into the sampling chamber without the volume of fluid contacting the pump;
- wherein the valve is configured to prevent backflow of fluid from the sampling chamber to the sample source.
A bioprocessing system, comprising:
- a cell culture vessel;
- a first assembly for adding a first fluid to the cell culture vessel, the first assembly including:
- a first chamber configured for fluid connection to a source of the first fluid via an inlet port in the first chamber, and for fluid connection to the cell culture vessel via an outlet port in the first chamber;
- a first pump device configured for fluid connection with the first chamber;
- a first valve intermediate the first chamber and the source, the first valve permitting unidirectional flow from the source to the first chamber;
- and
- a second valve intermediate the first chamber and the cell culture vessel, the second valve permitting unidirectional flow from the first chamber to the cell culture vessel;
- wherein the first pump device is selectively actuatable to draw a volume of the first fluid from the source into the first chamber, and to push the volume of fluid from the first chamber into the cell culture vessel;
- a second assembly for removing a second fluid from the cell culture vessel, the second assembly including:
- a second chamber configured for fluid connection to the cell culture vessel via an inlet port in the second chamber, and for fluid connection to a collection vessel via an outlet port in the second chamber;
- a second pump device configured for fluid connection with the second chamber;
- a third valve intermediate the cell culture vessel and the second chamber, the third valve permitting unidirectional flow from the cell culture vessel to the second chamber;
- and
- a fourth valve intermediate the second chamber and the collection vessel, the fourth valve permitting unidirectional flow from the second chamber to the collection vessel;
- wherein the second pump device is selectively actuatable to draw a volume of the second fluid from the cell culture vessel into the second chamber, and to push the volume of fluid from the second chamber into the collection vessel.
12 more elements
Dependencies are inferred from the claim text.