Cyclic(alkyl)(amino)alkoxy-substituted aryl-pyrone compound and use thereof
AssigneesShanghai Institute of Materia Medica, Chinese Academy of Sciences, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
InventorsChenggang HUANG, Xiaolan CUI, Yang XIE, Xiaoting TIAN, Shanshan GUO, Zhixiong LI, Yingjie GAO
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Abstract
A novel compound represented by general formula I, a pharmaceutically acceptable salt thereof, a solvate, a stereoisomer including mixtures thereof in all ratios, and a pharmaceutical composition containing the compound are provided. Also provided are preparation method for the compound, and applications of the compound, the pharmaceutically acceptable salt thereof, the solvate, and the stereoisomer including the mixtures in all ratios, and in particular to a use of the compound in the preparation of antiviral drugs.
Claims10
A compound shown in formula I, or a pharmaceutically acceptable salt, solvate, optically pure isomer, stereoisomer, or mixture thereof.
- wherein X1, X2 are each independently selected from the group consisting of:
- O, NR7;
- wherein said R7 is selected from the group consisting of:
- a hydrogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, cycloalkyl, substituted cycloalkyl;
- X3 is selected from the following group:
- O, NR8;
- wherein said R8 is selected from the following group:
- hydrogen, alkyl;
- R1a, R1b, R1c are each independently selected from the following group:
- a hydrogen, hydroxyl, alkoxy;
- R2 is selected from the following group:
- a substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
- R3a, R3b are each independently selected from the following group:
- a hydrogen, alkyl, halogen;
- R4a, R4b are each independently selected from the following group:
- a hydrogen, alkyl, halogen;
- R8 is selected from the following group:
- a hydrogen or alkoxy;
- R6 is selected from the following group:
- a hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted arylalkyl, aminoalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted C2-C6 acyl, substituted or unsubstituted alkoxycarbonyl, substituted or unsubstituted carbamoyl, or (CH2)tR7;
- wherein t is 1, 2, 3, 4, 5 or 6;
- wherein said R7 is selected from the following group:
- a C2-C6 acyl, C2-C6 amido, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylNR8COR9;
- Said R8 is selected from the following group:
- a hydrogen, alkyl;
- R9 is selected from the following group:
- an alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl;
- The A ring is a substituted or unsubstituted cycloalkyl;
- n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
- Wherein each “substituted” means that a hydrogen atom on a group is replaced by one or more substituents selected from the group consisting of:
- a cyano, halogen, alkyl, hydroxy, alkoxy, alkenyl, alkynyl, aryl, heteroaryl;
- and, said compound of formula I does not comprise
- In the above formulae, unless otherwise specified, the alkyl group is a C1-C6 alkyl group of, the aryl group is a C6-C10 aryl group, the cycloalkyl group is a C3-C8 cycloalkyl group, the alkoxy group is a C1-C6 alkoxy group, the alkenyl group is a C2-C6 alkenyl group, the alkynyl group is a C2-C6 alkynyl group, and the heteroaryl group is a heteroaryl group of 5-12 members (more preferably, 5-7 members).
Dependencies are inferred from the claim text.