# US 2025/0152818 A1 · Auto-injector and related methods of use

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- Number: US 2025/0152818 A1
- Document ID: US20250152818A1
- Status: Published application
- Kind: A1
- Application number: 19/019,611
- Filed: 2025-01-14
- Published: 2025-05-15
- Earliest claimed: 2017-05-05
- Assignees: Regeneron Pharmaceuticals, Inc.
- Applicants: Regeneron Pharmaceuticals, Inc.
- Inventors: Bryan C. Grygus; Alfred MARINO; Rachel P. ARNOTT; Scott BARTON; Bart E. BURGESS; Richard GILDERSLEEVE; Alexei GORALTCHOUK; Daniel HALBIG; Christopher KANEL; Trevor LANGLEY
- Web page: https://patentgrep.com/patent/US20250152818A1

## CPC

- A61M 5/20: Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 takes precedence)
- A61M 5/2033: {Spring-loaded one-shot injectors with or without automatic needle insertion (multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287)}
- A61M 5/001: {Apparatus specially adapted for cleaning or sterilising syringes or needles}
- A61M 5/3202: {Devices for protection of the needle before use, e.g. caps (A61M5/50 takes precedence; protectors for sharps A61B50/3001)}
- A61M 5/3204: {Needle cap removers, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices}
- A61M 5/326: {Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user}
- A61M 5/3287: {Accessories for bringing the needle into the body; Automatic needle insertion (A61M5/20, A61M5/31525 take precedence)}
- A61M 5/46: having means for controlling depth of insertion
- A61M 5/206: {with automatic needle insertion}
- A61M 2005/14252: {with needle insertion means}
- A61M 2005/2013: {triggering of discharging means by contact of injector with patient body}
- A61M 2005/208: {Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin}
- A61M 2005/247: {with fixed or steady piercing means, e.g. piercing under movement of ampoule}
- A61M 2005/31588: {electrically driven}
- A61M 2205/103: rotating
- A61M 2209/088: on the body
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}

## Abstract

An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.

## Claims

### Claim 1

An injection device, comprising:
a housing;
a container disposed within the housing, the container enclosing a medicament; and
a fluid conduit having a piercing end, wherein the piercing end is configured to move from an undeployed position where the fluid conduit is entirely contained within the housing, to a deployed position where the piercing end of the fluid conduit extends outside of the housing;
wherein movement of the container relative to the housing is configured to cause the piercing end of the fluid conduit to move from the deployed position to a third position where the fluid conduit is entirely contained with the housing.

### Claim 2 (depends on 1)

The injection device of claim 1, wherein the undeployed position and the third position are the same.

### Claim 3 (depends on 1)

The injection device of claim 1, further including a piston disposed within the container, wherein movement of the piston in a first direction from a first end of the container toward a second end of the container, while the piercing end of the fluid conduit is in the deployed position, urges medicament out of the container and into the fluid conduit.

### Claim 4 (depends on 3)

The injection device of claim 3, wherein movement of the container in a second direction, opposite of the first direction, causes the piercing end of the fluid conduit to move from the deployed position to the third position.

### Claim 5 (depends on 4)

The injection device of claim 4, further including:
a motor configured to drive the piston; and
a controller coupled to the motor, wherein the controller is configured to:
send a first signal to the motor to drive the piston in the first direction; and
send a second signal to the motor to drive the piston in the second direction.

### Claim 6 (depends on 5)

The injection device of claim 5, wherein the controller is configured to send the second signal without requiring any intervention by a user after sending the first signal.

### Claim 7 (depends on 1)

The injection device of claim 1, further including:
a driver coupled to the fluid conduit, the driver being slidable relative to the housing between a retracted configuration and a deployed configuration;
a shuttle configured to move the driver between the retracted configuration and the deployed configuration; and
a stop configured to move from a first configuration to a second configuration, wherein:
the stop is configured to maintain the driver in the deployed configuration,
movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration; and
movement of the container causes the stop to move from the first configuration to the second configuration.

### Claim 8 (depends on 7)

The injection device of claim 7, wherein movement of the stop from the first configuration to the second configuration includes flexion of the stop about a fixed end.

### Claim 9 (depends on 8)

The injection device of claim 8, wherein the stop includes a free end movable relative to the fixed end of the stop, and the stop is configured to maintain the driver in the deployed configuration when the free end of the stop contacts the shuttle.

### Claim 10 (depends on 9)

The injection device of claim 9, wherein the flexion of the stop about the fixed end moves the free end of the stop out of contact with the shuttle, allowing the shuttle to move the driver from the deployed configuration to the retracted configuration.

### Claim 11 (depends on 8)

The injection device of claim 8, wherein:
the stop includes a first inclined surface;
the injection device further includes a ramp having a second inclined surface that abuts the first inclined surface; and
movement of the container is configured to push the ramp against the stop to cause the flexion of the stop.

### Claim 12 (depends on 8)

The injection device of claim 8, further including a carrier inside the housing, wherein:
the carrier includes the stop; and
the shuttle is movable relative to the carrier.

### Claim 13 (depends on 7)

The injection device of claim 7, wherein the shuttle is movable from a first position to a second position, and from the second position to a third position, wherein:
when the shuttle is in the first position, the driver is in the retracted configuration;
when the shuttle is in the second position, the driver is in the deployed configuration; and
when the shuttle is in the third position, the driver is in the retracted configuration.

### Claim 14 (depends on 13)

The injection device of claim 13, wherein the first position and the third position are different.

### Claim 15 (depends on 14)

The injection device of claim 14, wherein the shuttle moves in one direction along an axis to move from the first position to the second position, and from the second position to the third position.

### Claim 16 (depends on 15)

The injection device of claim 15, wherein the shuttle is configured to move only in the one direction.

### Claim 17

An injection device, comprising:
a housing;
a container disposed within the housing, the container including a first end and a second end;
a piston sealing the first end of the container, wherein the piston is movable through the container, in a first direction from the first end toward the second end of the container, to dispense the medicament; and
a needle having a piercing end, wherein the piercing end is configured to move from an undeployed position where the needle is entirely contained within the housing, to a deployed position where the piercing end of the needle extends outside of the housing;
wherein movement of the container in a second direction, opposite of the first direction, is configured to cause the piercing end of the needle to move from the deployed position to a third position where the needle is entirely contained with the housing.

### Claim 18 (depends on 17)

The injection device of claim 17, wherein the undeployed position and the third position are the same.

### Claim 19

A method of operating an injector, the method comprising:
activating the injector to cause a piercing end of a fluid conduit entirely enclosed within a housing of the injector, to extend outside of the housing and pierce a user;
wherein activating the injector further causes:
(1) medicament to be dispensed from a container into the fluid conduit, while the piercing end of the fluid conduit is disposed within the user, wherein the container is entirely disposed within the housing; and
(2) the container to move relative to the housing to cause the piercing end of the fluid conduit to retract from the user entirely into the housing.

### Claim 20 (depends on 19)

The method of claim 19, wherein the medicament is dispensed and the container is moved without any additional intervention by the user after the activating step.

### Claim 21

A method for delivering a medicament from an injector, the method comprising:
upon activation of the injector by a user:
(1) extending a piercing end of a fluid conduit entirely enclosed within a housing of the injector, to outside of the housing to pierce the user;
(2) dispensing medicament from a container into the fluid conduit, while the piercing end of the fluid conduit is disposed within the user, wherein the container is entirely disposed within the housing; and
(3) moving the container relative to the housing to cause the piercing end of the fluid conduit to retract from the user entirely into the housing.

### Claim 22 (depends on 21)

The method of claim 21, wherein activation of the injector occurs by the user pressing a button coupled to the housing.