# US 2025/0152003 A1 · Measuring biomechanical and birefringent properties of eye tissue > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0152003 A1 - Document ID: US20250152003A1 - Status: Published application - Kind: A1 - Application number: 18/943,137 - Filed: 2024-11-11 - Published: 2025-05-15 - Earliest claimed: 2023-11-14 - Assignees: Alcon Inc. - Applicants: Alcon Inc. - Inventors: Gangjun Liu; Lingfeng Yu; Yilin Zhao - Web page: https://patentgrep.com/patent/US20250152003A1 ## CPC - A61B 3/102: {for optical coherence tomography [OCT]} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract In certain embodiments, an ophthalmic diagnostics system includes a polarization sensitive optical coherence tomography (PS-OCT) device. The system also includes a memory having executable instructions. The system also includes a processor in communication with the memory and configured to execute the instructions to cause the PS-OCT device to emit polarized light to a measurement location on eye tissue of a patient and generate PS-OCT data based on the polarized light. The processor is further configured to execute the instructions to determine birefringent information for the measurement location based on the PS-OCT data and to determine biomechanics information for the measurement location based on the PS-OCT data. The processor is further configured to execute the instructions to determine a correlation between at least a portion of the biomechanics information and at least a portion of the birefringent information. ## Claims ### Claim 1 An ophthalmic diagnostics system, comprising: a polarization sensitive optical coherence tomography (PS-OCT) device; a memory comprising executable instructions; a processor in communication with the memory and configured to execute the instructions to: cause the PS-OCT device to: emit polarized light to a measurement location on eye tissue of a patient; and generate PS-OCT data based on the polarized light, determine birefringent information for the measurement location based on the PS-OCT data; determine biomechanics information for the measurement location based on the PS-OCT data; and determine a correlation between at least a portion of the biomechanics information and at least a portion of the birefringent information. ### Claim 2 (depends on 1) The ophthalmic diagnostics system of claim 1, wherein the processor is further configured to execute the instructions to receive an indication of a stimulus applied to the eye tissue, wherein the emission of polarized light to the PS-OCT device is in response to the received indication. ### Claim 3 (depends on 2) The ophthalmic diagnostics system of claim 2, wherein: the PS-OCT device comprises a vertical polarization sensitive detector and a horizontal polarization sensitive detector; the PS-OCT data comprises first PS-OCT data from the vertical polarization sensitive detector and second PS-OCT data from the horizontal polarization sensitive detector; and the biomechanics information comprises first biomechanics information determined based on the first PS-OCT data and second biomechanics information determined based on the second PS-OCT data. ### Claim 4 (depends on 3) The ophthalmic diagnostics system of claim 3, wherein the first biomechanics information comprises a first vibration amplitude and the second biomechanics information comprises a second vibration amplitude. ### Claim 5 (depends on 3) The ophthalmic diagnostics system of claim 3, wherein the first biomechanics information comprises a first quantification of tissue stiffness and the second biomechanics information comprises a second quantification of tissue stiffness. ### Claim 6 (depends on 1) The ophthalmic diagnostics system of claim 1, wherein the birefringent information comprises at least one of phase retardance, degree of polarization uniformity, or birefringent axial orientation. ### Claim 7 (depends on 1) The ophthalmic diagnostics system of claim 1, wherein at least a portion of the biomechanics information is determined based on at least a portion of the birefringent information. ### Claim 8 (depends on 7) The ophthalmic diagnostics system of claim 7, wherein the determination of the biomechanics information comprises a determination of change in a reflectance property with time via at least one of phase decorrelation or intensity variance. ### Claim 9 (depends on 1) The ophthalmic diagnostics system of claim 1, wherein the processor is further configured to execute the instructions to at least one of record or display data related to the correlation. ### Claim 10 (depends on 1) The ophthalmic diagnostics system of claim 1, wherein the eye tissue comprises a cornea of the patient. ### Claim 11 A method of operating an ophthalmic diagnostics system comprising a polarization sensitive optical coherence tomography device (PS-OCT) device, the method comprising: emitting, by the ophthalmic diagnostics system, polarized light to a measurement location on eye tissue of a patient; generating, by the ophthalmic diagnostics system, PS-OCT data for the measurement location based on the polarized light; determining, by the ophthalmic diagnostics system, birefringent information for the measurement location based on the PS-OCT data; determining, by the ophthalmic diagnostics system, biomechanics information for the measurement location based on the PS-OCT data; and determining, by the ophthalmic diagnostics system, a correlation between at least a portion of the biomechanics information and at least a portion of the birefringent information. ### Claim 12 (depends on 11) The method of claim 11, further comprising receiving an indication of a stimulus applied to the eye tissue, wherein the emitting is performed in response to the received indication. ### Claim 13 (depends on 12) The method of claim 12, wherein: the PS-OCT device comprises a first polarization sensitive detector and a second polarization sensitive detector; the generating comprises generating first PS-OCT data by the first polarization sensitive detector and second PS-OCT data by the second polarization sensitive detector; and the determining biomechanics information comprises determining first biomechanics information based on the first PS-OCT data and second biomechanics information based on the second PS-OCT data. ### Claim 14 (depends on 13) The method of claim 13, wherein the first biomechanics information comprises a first vibration amplitude and the second biomechanics information comprises a second vibration amplitude. ### Claim 15 (depends on 13) The method of claim 13, wherein the first biomechanics information comprises a first quantification of tissue stiffness and the second biomechanics information comprises a second quantification of tissue stiffness. ### Claim 16 (depends on 11) The method of claim 11, wherein the birefringent information comprises at least one of phase retardance, degree of polarization uniformity, or birefringent axial orientation. ### Claim 17 (depends on 11) The method of claim 11, wherein at least a portion of the biomechanics information is determined based on at least a portion of the birefringent information. ### Claim 18 (depends on 17) The method of claim 17, wherein the determining biomechanics information comprises determining change in a reflectance property with time via at least one of phase decorrelation or intensity variance. ### Claim 19 (depends on 11) The method of claim 11, further comprising at least one of recording or displaying data related to the correlation. ### Claim 20 (depends on 11) The method of claim 11, wherein the eye tissue comprises a cornea of the patient.