# US 2025/0151997 A1 · Systems and methods for retinal stimulation and/or collecting retinal signal data

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- Number: US 2025/0151997 A1
- Document ID: US20250151997A1
- Status: Published application
- Kind: A1
- Application number: 18/836,807
- Filed: 2023-02-09
- Published: 2025-05-15
- Earliest claimed: 2022-02-09
- Assignees: Diamentis Inc.
- Applicants: Diamentis Inc.
- Inventors: Claude HARITON
- Web page: https://patentgrep.com/patent/US20250151997A1

## CPC

- A61B 3/10: Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B 3/12: for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence)
- A61B 3/0008: {provided with illuminating means (A61B3/117, A61B3/14 take precedence)}
- A61B 3/112: {for measuring diameter of pupils}
- A61B 3/14: Arrangements specially adapted for eye photography
- A61B 3/156: {for blocking}
- A61B 5/297: for electrooculography [EOG]: for electroretinography [ERG]
- A61B 5/315: for electrooculography [EOG]; for electroretinography [ERG]
- A61B 5/398: Electrooculography [EOG], e.g. detecting nystagmus; Electroretinography [ERG]
- A61B 2560/0238: Means for recording calibration data
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

There is disclosed a method and system for retinal stimulation and retinal signal data collection. The system comprises a housing. The housing supports one or more light sources that are configured to expose a retina of an eye of an individual to a flash of light. The housing supports a spectrometer that is configured to record a light spectrum and an intensity of the flash of light. The housing supports a camera configured to capture image data of the eye while exposed to the flash of light.

## Claims

### Claim 1

An apparatus for retinal stimulation, the apparatus comprising a housing supporting:
one or more light sources configured to expose a retina of an eye of an individual to a flash of light;
a spectrometer configured to record a light spectrum and an intensity of the flash of light; and
a camera configured to capture image data of the eye exposed to the flash of light.

### Claim 2 (depends on 1)

The apparatus of claim 1, wherein the apparatus is a head-worn apparatus to be worn on a head of the individual.

### Claim 3 (depends on 1, 2)

The apparatus of any one of claims 1-2, wherein the apparatus comprises an eye shade for enclosing the eye of the individual, and wherein the eye shade is configured to block external light from entering the eye of the individual.

### Claim 4 (depends on 1, 2, 3)

The apparatus of any one of claims 1-3, further comprising a light reflector configured to direct light from the one or more light sources towards the eye of the individual.

### Claim 5 (depends on 1, 2, 3, 4)

The apparatus of any one of claims 1-4, further comprising a controller communicatively coupled to the one or more light sources, the spectrometer and the camera, wherein the controller is configured to adjust a parameter of the one or more light sources based on data from the spectrometer.

### Claim 6 (depends on 5)

The apparatus of claim 5, wherein the controller comprises a control circuit supported by the housing and configured to receive data from the spectrometer.

### Claim 7 (depends on 5, 6)

The apparatus of any one of claims 5-6, wherein the camera is in communication with the controller, and wherein the controller executes instructions that determine, based on data received from the camera, one or more of:
a position of the eye of the individual,
a pupil size of the eye of the individual, and
a pupil shape of the eye of the individual.

### Claim 8 (depends on 1, 2, 3, 4, 5, 6, 7)

The apparatus of any one of claims 1-7, further comprising one or more electrodes attachable to the individual and configured to collect electrical signals from the individual.

### Claim 9 (depends on 5, 6, 7)

The apparatus of any one of claims 5-7, further comprising:
one or more electrodes attachable to the individual and configured to collect electrical signals from the individual, the one or more electrodes communicatively connectable to the controller, the controller being configured to receive electrical signal data from the electrodes.

### Claim 10 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9)

The apparatus of any one of claims 1-9, further comprising a battery for providing power to one or more of: the one or more light sources, the spectrometer, and the camera.

### Claim 11 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

The apparatus of any one of claims 1-10, further comprising a networking device.

### Claim 12 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11)

The apparatus any one of claims 1-11, further comprising a safety module configured to monitor a temperature of the apparatus.

### Claim 13 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)

The apparatus of any one of claims 1-12, further comprising one or more amplifiers and one or more filters.

### Claim 14 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)

The apparatus of any one of claims 1-13, wherein the one or more light sources comprise a light emitting diode (LED).

### Claim 15 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)

The apparatus of any one of claims 1-14, wherein the one or more light sources, the spectrometer and the camera define a first sub-system configured for retinal stimulation of a first eye of the individual, the apparatus further comprising a second sub-system configured for retinal stimulation for a second eye of the individual, the second sub-system comprising another set of one or more light sources, spectrometer and camera.

### Claim 16 (depends on 15)

The apparatus of claim 15, wherein the one or more light sources and the another set of one or more light sources are configured to output flashes of light simultaneously.

### Claim 17 (depends on 5)

The apparatus of claim 5, wherein the controller is configured to determine one or more of:
a distance between the camera and an iris of the eye,
a distance between the one or more light sources and the iris of the eye,
a pupil size of the eye,
a pupil shape of the eye,
an eye position of the eye, and
the area of a retina of the eye that was exposed to the flash of light.

### Claim 18 (depends on 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)

A system for retinal stimulation, the system comprising the apparatus of any one of claims 1-17, and a processor of a computer system configured to send instructions to, and/or receive data from, the one or more light sources, the spectrometer and the camera.

### Claim 19 (depends on 18)

The system of claim 18, wherein the processor is configured to adjust a parameter of the one or more light sources based on data from the spectrometer.

### Claim 20

A method for collecting retinal signal data, the method configured to be executed by a processor of a system for collecting retinal signal data, the method comprising:
causing one or more light sources to output a flash of light at a selected wavelength and a selected intensity to an individual;
receiving, from a camera, an image of an eye of the individual; and
determining, based on the image, an area of a retina of the eye that was exposed to the flash of light.

### Claim 21 (depends on 20)

The method of claim 20, further comprising determining, based on the image, a distance between the camera and an iris of the eye, and wherein determining the area of the retina comprises determining, based on the distance between the camera and the iris, the area of the retina that was exposed to the flash of light.

### Claim 22 (depends on 20)

The method of claim 20, further comprising determining, based on the image, a distance between the one or more light sources and an iris of the eye, and wherein determining the area of the retina comprises determining, based on the distance between the one or more light sources and the iris, the area of the retina that was exposed to the flash of light.

### Claim 23 (depends on 20)

The method of claim 20, further comprising determining, based on the image, a pupil size, or shape, or area of the eye, and wherein determining the area of the retina comprises determining, based on the pupil size, or shape, or area, the area of the retina that was exposed to the flash of light.

### Claim 24 (depends on 20)

The method of claim 20, further comprising determining, based on the image, a position of the eye, and wherein determining the area of the retina comprises determining, based on the position of the eye, the area of the retina that was exposed to the flash of light.

### Claim 25

A system for collecting retinal signal data, the system comprising:
one or more light sources configured to expose a retina of an eye of an individual to a flash of light;
a spectrometer configured to record a light spectrum and an intensity of the flash of light; and
a controller communicatively coupled to one or more of: the one or more light sources, and the spectrometer, wherein the controller is configured to:
adjust a parameter of the one or more light sources based on data from the spectrometer,
cause the retina to be exposed to an adjusted flash of light, and
receive electrical signals produced by the retina of the individual in response to the adjusted flash of light.

### Claim 26 (depends on 25)

The system of claim 25, wherein the controller comprises a processor of a computer system communicatively couplable with the one or more light sources, and the spectrometer.

### Claim 27 (depends on 25)

The system of claim 25, wherein the controller comprises a control circuit, wherein the control circuit is communicatively coupled to the one or more light sources, and wherein the control circuit is communicatively coupled to the spectrometer and configured to receive data from the spectrometer.

### Claim 28 (depends on 25, 26, 27)

The system of any of claims 25-27, further comprising a light reflector configured to direct light from the one or more light sources towards the eye of the individual, wherein the light reflector is spheroidal and includes an eye shade portion around a light outlet of the light reflector, the eye shade portion being configured to enclose the eye of the individual, and wherein the eye shade portion is configured to minimize or block external light from entering a housing of the system.

### Claim 29 (depends on 25, 26, 27, 28)

The system of any one of claims 25-28, further comprising one or more electrodes attachable to the individual and which are communicatively couplable with the controller, and wherein the electrodes are configured to collect the electrical signals produced by the retina of the individual.

### Claim 30 (depends on 25, 26, 27, 28, 29)

The system of any one of claims 25-29, further comprising a battery for providing power to one or more of: the one or more light sources, and the spectrometer.

### Claim 31 (depends on 25, 26, 27, 28, 29, 30)

The system of any one of claims 25-30, further comprising a camera, wherein the camera is in communication with the controller, and wherein the controller is configured to execute instructions that determine, based on data received from the camera, one or more of:
a position of the eye of the individual,
a pupil size of the eye of the individual, and
a pupil shape of the eye of the individual.

### Claim 32 (depends on 25, 26, 27, 28, 29, 30, 31)

The system of any one of claims 25-31, further comprising one or more of: a networking device, a safety module configured to monitor a temperature of the system, one or more amplifiers, and one or more filters.

### Claim 33 (depends on 25, 26, 27, 28, 29, 30, 31, 32)

The system of any one of claims 25-32, further comprising a housing, wherein the housing is configured to support the one or more light sources and the spectrometer, wherein the housing has a portion for enclosing the eye of the individual, and wherein the housing has a wearable configuration.

### Claim 34 (depends on 33)

The system of claim 33, wherein the housing comprises a helmet to be worn on a head of the individual, or eye wear configured to be worn over eyes.

### Claim 35 (depends on 34)

The system of claim 34, wherein the helmet or the eye wear comprises one or more straps to secure the helmet or the eye wear to the individual.

### Claim 36 (depends on 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)

The system of any one of claims 25-35, wherein the one or more light sources comprise a light emitting diode (LED).

### Claim 37 (depends on 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)

The system of any one of claims 25-36 wherein the one or more light sources, and the spectrometer define a first sub-system configured for retinal stimulation of a first eye of the individual, the system further comprising a second sub-system configured for retinal stimulation of a second eye of the individual, the second sub-system comprising another set of one or more light sources, and another spectrometer.

### Claim 38 (depends on 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)

The system of any one of claims 25-37, wherein the parameter comprises a wavelength of the one or more light sources or an intensity of the one or more light sources.

### Claim 39

A method for collecting retinal signal data, the method configured to be executed by a processor of a system for collecting retinal signal data, the method comprising:
causing one or more light sources to output a first flash of light at a selected wavelength and a selected intensity to an individual;
receiving, from a spectrometer, a measured wavelength and a measured intensity of the first flash of light;
determining that the measured wavelength and the measured intensity is not within a pre-determined tolerance of the selected wavelength and the selected intensity;
determining, based on a difference between the selected wavelength and the measured wavelength, and based on a difference between the selected intensity and the measured intensity, parameters for a second flash of light;
causing the one or more light sources to output the second flash of light based on the parameters; and
receiving, from a sensor associated with the individual, retinal signal data of the individual responsive to the second flash of light.

### Claim 40 (depends on 39)

The method of claim 39, further comprising receiving, from the sensor, retinal signal data of the individual responsive to the first flash of light.

### Claim 41 (depends on 39, 40)

The method of any one of claims 39-40, wherein the one or more light sources and the spectrometer are integrated in a housing of an apparatus, wherein the apparatus further comprises a camera, and wherein the method further comprises:
receiving, from the camera, data regarding a pupil of the individual; and
determining, based on the data from the camera, one or both of a pupil size and a pupil shape when viewed from a fixed point of the individual that was exposed to the second flash of light.

### Claim 42 (depends on 41)

The method of claim 41, further comprising determining, based on the data from the camera, an area of the retina of the individual that was exposed to the second flash of light.

### Claim 43 (depends on 41)

The method of claim 41, further comprising adjusting, based on the one or both of the pupil size and the pupil shape, the retinal signal data, or determining, based on the one or both of the pupil size and the pupil shape, to re-record the retinal signal data.

### Claim 44 (depends on 39, 40, 41, 42, 43)

The method of any one of claims 39-43, further comprising:
receiving calibration data corresponding to the individual;
determining, based on the calibration data, a threshold impedance of a circuit that collected the retinal signal data;
determining that an impedance of the circuit has surpassed the threshold impedance; and
after determining that the impedance of the circuit has surpassed the threshold impedance, re-recording the retinal signal data.

### Claim 45

A system for collecting retinal signal data, the system comprising:
one or more light sources configured to expose a retina of an eye of an individual to flashes of light; and
a spectrometer configured to record a light spectrum and an intensity of the flashes of light, wherein the system is configured to collect electrical signals produced by the retina of the individual in response to the flash of light; and
at least one processor and memory storing executable instructions which, when executed by the at least one processor, cause the system to:
output, by the one or more light sources, a first flash of light at a selected wavelength and a selected intensity to the individual;
receive, from the spectrometer, a measured wavelength and a measured intensity of the first flash of light;
determine that the measured wavelength and the measured intensity is not within a pre-determined tolerance of the selected wavelength and the selected intensity;
determine, based on a difference between the selected wavelength and the measured wavelength, and based on a difference between the selected intensity and the measured intensity, parameters for a second flash of light;
cause the one or more light sources to output the second flash of light based on the parameters; and
receive, from an electrode associated with the individual, retinal signal data of the individual responsive to the second flash of light.

### Claim 46 (depends on 45)

The system of claim 45, wherein the retinal signal data comprises data from the spectrometer.

### Claim 47 (depends on 45, 46)

The system of any one of claims 45-46, wherein the instructions further cause the system to:
receive calibration data corresponding to the individual;
determine, based on the calibration data, a threshold impedance of a circuit that collected the retinal signal data;
determine that an impedance of the circuit has surpassed the threshold impedance; and
after determining that the impedance of the circuit has surpassed the threshold impedance, re-record the retinal signal data.

### Claim 48 (depends on 45, 46, 47)

The system of any one of claims 45-47, further comprising a camera, and wherein the instructions further cause the system to determine, based on the data from the camera, a pupil size and shape of the individual that was exposed to the second flash of light.

### Claim 49 (depends on 45, 46, 47, 48)

The system of any one of claims 45-48, wherein the instructions further cause the system to receive, from the electrode, retinal signal data of the individual responsive to the first flash of light.
