Surface-induced dissociation devices and methods
AssigneeOhio State Innovation Foundation
InventorsSean CLEARY, Chen DU, Vicki WYSOCKI
Life of this patent
Estimating the term…
Abstract
Systems and methods for surface-induced dissociation (SID) are disclosed herein. According to one embodiment of the present disclosure, a system for characterizing the structure of a sample includes an SID device configured to receive the sample, the sample including a plurality of viral capsids; a charge detection mass spectrometer (CDMS) operably coupled to the surface induced dissociation device and configured to receive fragmented viral capsids from the surface induced dissociation device, where the CDMS is configured to determine a characterization of the structure of the viral capsids.
Claims22
A system for characterizing the structure of a sample, comprising:
- a surface induced dissociation (SID) device configured to receive the sample, the sample comprising viral capsids;
- a charge detection mass spectrometer (CDMS) operably coupled to the SID device and configured to receive fragmented viral capsids from the SID device, wherein the CDMS is configured to determine a characterization of the structure of the viral capsids.
A method of characterizing the structure of viral capsids, comprising:
- inputting a plurality of viral capsids into an SID device;
- fragmenting the plurality of viral capsids using the SID device to create a plurality of viral capsid fragments;
- inputting the plurality of viral capsid fragments into a CDMS;
- determining a characterization of the plurality of viral capsids using the CDMS;
- and
- outputting a plurality of peaks.
(canceled)
A method of characterizing the structure of sample, comprising:
- inputting the sample into an SID device, the sample comprising a plurality of viral capsids and an impurity, wherein the SID device is configured to fragment the impurity without fragmenting the viral capsids;
- fragmenting the impurity using the SID device;
- inputting the plurality of viral capsids into a CDMS;
- and
- determining a characterization of the plurality of viral capsids using the CDMS.
(canceled)
Dependencies are inferred from the claim text.