# US 2025/0146969 A1 · Multi-sensor and early diagnosis system using same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0146969 A1 - Document ID: US20250146969A1 - Status: Published application - Kind: A1 - Application number: 18/933,527 - Filed: 2024-10-31 - Published: 2025-05-08 - Earliest claimed: 2023-11-03 - Assignees: Industry-Academic Cooperation Foundation, Yonsei University - Applicants: Industry-Academic Cooperation Foundation, Yonsei University - Inventors: Seong Chan JUN; Yun Ji HWANG; Tae Jong HWANG; Jong Woo HONG; TIANCI LIU - Web page: https://patentgrep.com/patent/US20250146969A1 ## CPC - G01N 27/27: Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter - A61B 5/082: {Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath (A61B5/083, A61B5/091 take precedence)} - G01N 27/3275: {Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction} - G01N 33/5308: {for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites} - G01N 33/5438: {Electrodes} - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract An embodiment provides a multi-sensor and an early diagnosis system using the same, wherein the multi-sensor diagnoses a disease by using deep learning technology after obtaining a plurality of different electric signals obtained through reactions with target materials that respectively contact a plurality of sensors equipped in the multi-sensor. ## Claims ### Claim 1 A multi-sensor, comprising: a substrate portion; a sensor portion comprising a plurality of sensors arranged in a matrix on the substrate portion; a plurality of electrode portions arranged radially from a center of the sensor portion on the substrate portion and electrically connected to the plurality of sensors; and a multi-channel portion positioned above the plurality of sensors where a plurality of body holes are defined for target materials to be introduced, wherein the plurality of sensors configured to generate different electric signals for the target materials and transmit the different electric signals to the plurality of electrode portions, respectively. ### Claim 2 (depends on 1) The multi-sensor of claim 1, wherein the target materials, which are liquid protein separated from blood, comprise alpha synuclein, beta amyloid, and tau protein. ### Claim 3 (depends on 2) The multi-sensor of claim 2, wherein the different electric signals are different electrical reactive signals, and the plurality of sensors interact with the target materials to generate the different electrical reactive signals to detect a cause material of a degenerative neurological disease and transmit the different electrical reactive signals to the plurality of electrode portions, respectively. ### Claim 4 (depends on 2) The multi-sensor of claim 2, wherein the plurality of sensors are made of different graphene oxides and configured to generate the different electric signals due to changes in properties of the different graphene oxides through interactions with the target materials. ### Claim 5 (depends on 1) The multi-sensor of claim 1, wherein the target materials, which are an analysis target gas that is an animal's exhaled gas, comprise ammonia, hydrogen sulfide, and nitrogen monoxide. ### Claim 6 (depends on 5) The multi-sensor of claim 5, wherein the different electric signals are different electrochemical signals, and the plurality of sensors generate the different electrochemical signals to diagnose at least one of liver, kidney, gastric ulcer, duodenal ulcer, odor-related disease, lung cancer, and pancreatitis, and transmit the different electrochemical signals to the plurality of electrode portions, respectively. ### Claim 7 (depends on 2) The multi-sensor of claim 2, wherein the plurality of sensors include an upper sensor positioned on an upper surface of the substrate portion and arranged in a first row, a central sensor positioned on the upper surface of the substrate portion and arranged in a second row below the upper sensor, and a lower sensor positioned on the upper surface of the substrate portion and arranged in a third row below the central sensor, wherein the upper sensor is a second reduced graphene oxide, the central sensor is a first reduced graphene oxide, and the lower sensor is a graphene oxide. ### Claim 8 (depends on 5) The multi-sensor of claim 5, wherein an ssDNA-bound graphene comprises a first graphene functionalized with one type of ssDNA and a second graphene functionalized with two types of ssDNA, wherein the plurality of sensors include an upper sensor positioned on an upper surface of the substrate portion and arranged in a first row, a central sensor positioned on the upper surface of the substrate portion and arranged in a second row below the upper sensor, and a lower sensor positioned on the upper surface of the substrate portion and arranged in a third row below the central sensor, and wherein the upper sensor is the first graphene functionalized with the one type of ssDNA, the central sensor is the second graphene functionalized with the two types of ssDNA, and the lower sensor is a single graphene. ### Claim 9 (depends on 1) An early diagnosis system using a multi-sensor, the early diagnosis system comprising: the multi-sensor according to claim 1; a measuring device electrically connected to the plurality of electrode portions and measuring the different electric signals; and a diagnostic device configured to inputs the different electric signals transmitted from the measuring device into a deep learning model and then diagnose a disease through regression analysis, wherein the diagnostic device comprises a deep learning portion configured to improves a diagnostic speed by only using an encoding scheme configured to increases and then decreases a number of channels where the different electrical signals, which are one-dimensional signals, are each grouped. ### Claim 10 (depends on 9) The early diagnosis system of claim 9, wherein the target materials, which are liquid protein separated from blood, comprise alpha synuclein, beta amyloid, and tau protein, and the different electric signals are different electrical reactive signals, and wherein the diagnostic device comprises; a data storage portion configured to stores the different electric signals transmitted from the measuring device; and a diagnostic portion configured to simultaneously diagnoses Alzheimer's disease and Parkinson's disease by determining a presence and a mixing state of the alpha synuclein, the beta amyloid, and the tau protein. ### Claim 11 (depends on 10) The early diagnosis system of claim 10, wherein the diagnostic portion configured to diagnose a patient who provided the target materials as having the Alzheimer's disease when a mixing ratio of the alpha synuclein, the beta amyloid, and the tau protein is 3-5:6-14:2-3. ### Claim 12 (depends on 10) The early diagnosis system of claim 10, wherein the diagnostic portion configured to diagnose a patient who provided the target materials as having the Parkinson's disease when a mixing ratio of the alpha synuclein, the beta amyloid, and the tau protein is 5-13:4-8:1-3. ### Claim 13 (depends on 9) The early diagnosis system of claim 9, wherein the different electric signals are different electrochemical signals, and the target materials, which are an analysis target gas that is an animal's exhaled gas, comprise ammonia, hydrogen sulfide, and carbon monoxide, and wherein the diagnostic device comprises: a data storage portion configured to stores the different electrochemical signals transmitted from the measuring device; and diagnostic portion configured to diagnoses at least one of liver disease, kidney disease, gastric ulcer, duodenal ulcer, odor-related disease, lung cancer, and pancreatitis by determining a type and a composition ratio of the analysis target gas. ### Claim 14 (depends on 13) The early diagnosis system of claim 13, wherein the diagnostic portion configured to diagnoses the liver disease, kidney disease, gastric ulcer and duodenal ulcer when the ammonia is present in higher amounts than hydrogen sulfide and carbon monoxide. ### Claim 15 (depends on 13) The early diagnosis system of claim 13, wherein the diagnostic portion configured to diagnose the odor-related disease and pancreatitis when the hydrogen sulfide is present in higher amounts than the ammonia and carbon monoxide. ### Claim 16 (depends on 13) The early diagnosis system of claim 13, wherein the diagnostic portion configured to diagnoses lung cancer when the hydrogen sulfide and the carbon monoxide are in equal amounts among the ammonia, the hydrogen sulfide and the carbon monoxide.