Generation of deoxyadenosine triphosphate donor cells and uses thereof
AssigneeUniversity of Washington
InventorsMichael REGNIER, Charles E. MURRY, Stephen D. HAUSCHKA
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Abstract
Provided herein are compositions and methods directed toward the discovery of improved methods for generating deoxyATP (dATP) in cells that can be delivered to a graft site in the heart to enhance cardiac function.
Claims28
A dATP donor cell comprising a nucleic acid sequence encoding a ribonucleotide reductase expression cassette operably linked to a muscle-specific promoter.
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A dATP donor cell comprising a nucleic acid sequence encoding a ribonucleotide reductase expression cassette operably linked to a constitutively active promoter.
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Dependencies are inferred from the claim text.