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US 2025/0145669 A1Published application
Methods and compositions for the treatment of hepatitis b infection
AssigneeMelbourne Health
InventorsRenae Walsh, Stephen Locarnini, Hans Netter, Ronald Farquhar
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compositions and methods for the treatment of hepatitis B infection, including chronic hepatitis B (CHB).
Claims21
-74. (canceled)
A bio-nanoparticle (BNP) comprising a hepadnaviral envelope HBsAg-S fusion protein comprising one or two antigenic epitope repeat regions selected from the group consisting of:
- (i) a region comprising a first epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35) and a second epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35);
- (ii) a region comprising a first epitope consisting of the amino acid sequence CTKPSDGNC (SEQ ID NO:
- 54), a second epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34), and a third epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34);
- (iii) a region comprising a first epitope consisting of the amino acid sequence PCKTCTTP (SEQ ID NO:
- 28), a second epitope consisting of the amino acid sequence PCKTCTTP (SEQ ID NO:
- 28), and a third epitope consisting of the amino acid sequence PCKTCTTP (SEQ ID NO:
- 28);
- (iv) a region comprising a first epitope consisting of the amino acid sequence PCRTCTTP (SEQ ID NO:
- 33), a second epitope consisting of the amino acid sequence PCRTCTTP (SEQ ID NO:
- 33), and a third epitope consisting of the amino acid sequence PCRTCTTP (SEQ ID NO:
- 33);
- (v) a region comprising a first epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34), a second epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34), and a third epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34);
- (vi) a first region comprising a first epitope consisting of the amino acid sequence PCKTCTTP (SEQ ID NO:
- 28), a second epitope consisting of the amino acid sequence PCKTCTTP (SEQ ID NO:
- 28), and a third epitope consisting of the amino acid sequence PCRTCMTT (SEQ ID NO:
- 55) and a second region comprising a first epitope consisting of the amino acid sequence CTKPSDGNC (SEQ ID NO:
- 54), a second epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34), and a third epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34);
- and
- (vii) a region comprising a first epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35), a second epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35), and a third epitope consisting of the amino acid sequence PCRTCMTTAQGTSMYPS (SEQ ID NO:
- 48).
28 more elements
A composition comprising:
- a first bio-nanoparticle (BNP) comprising a hepadnaviral envelope HBsAg-S fusion protein comprising an antigenic epitope repeat region comprising a first epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35) and a second epitope consisting of the amino acid sequence CKTCTTPAQGNSMFPS (SEQ ID NO:
- 35);
- and
- a second bio-nanoparticle (BNP) comprising a hepadnaviral envelope HBsAg-S fusion protein comprising an antigenic epitope repeat region comprising a first epitope consisting of the amino acid sequence CTKPSDGNC (SEQ ID NO:
- 54), a second epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34), and a third epitope consisting of the amino acid sequence CTKPTDGNC (SEQ ID NO:
- 34).
5 more elements
Dependencies are inferred from the claim text.