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US 2025/0145654 A1Published application
Compounds and methods for treating disease
AssigneeROME Therapeutics, Inc.
InventorsDonna L. Romero, Oliver Saunders, Gregory Stuart Bisacchi, Dennis Zaller, Rosana Kapeller-Libermann
Life of this patent
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Abstract
The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.
Claims34
A compound represented by Formula V:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- B1 is
- R1 and R2 are defined as follows:
- (i) R1 is —H or —C(O)R8, and R2 is ethyl or ethenyl;
- or
- (ii) R1 is —C(O)R8, and R2 is ethynyl;
- R3 is —H;
- R4 is —OH or —OC(O)R8;
- R5 is —H;
- R6 is —H, fluoro, or —OH;
- R7 is halo;
- and
- R8 represents independently for each occurrence C1-20 aliphatic.
11 more elements
A compound represented by Formula III:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is —CH2CH3 or —C(H)═CH2;
- R2 is fluoro;
- R3 is halo;
- and
- B1 is
4 more elements
A compound represented by Formula IV:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is —CH2CH3;
- R2 is halo;
- and
- B1 is
3 more elements
Dependencies are inferred from the claim text.