# US 2025/0144598 A1 · Polymethylsiloxane polyhydrate having supramolecular properties of a molecular capsule, method for its production, and sorbent containing thereof

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- Number: US 2025/0144598 A1
- Document ID: US20250144598A1
- Status: Published application
- Kind: A1
- Application number: 18/927,024
- Filed: 2024-10-25
- Published: 2025-05-08
- Earliest claimed: 2023-11-02
- Assignees: Bioline Pharmaceutical AG
- Applicants: Bioline Pharmaceutical AG
- Inventors: Aleksandr Mykhailovich MARTYNENKO; Emil Gennadievich KADNICHANSKIY; Sergey Valentinovich BADAEV
- Web page: https://patentgrep.com/patent/US20250144598A1

## CPC

- B01J 20/265: {modified or post-treated polymers (polymer carriers or substrates subjected to further impregnating or coating B01J20/3208)}
- C08G 77/16: to hydroxy groups
- B01J 20/3085: {Chemical treatments not covered by groups B01J20/3007 - B01J20/3078}
- C08G 77/38: Polysiloxanes modified by chemical after-treatment
- B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS

## Abstract

The invention relates to a method for producing a sorbent having selective properties, and in particular to a method for producing polymethylsiloxane polyhydrate (methylsilicic acid hydrogel) used in chemistry, medicine, and veterinary medicine. According to the method, polycondensation of a metasil solution is carried out with acid, the said solution being obtained by mixing at temperatures above 90° C. in a ratio of 0.84-1.00 mol, and in the best embodiment of the invention—in the range of 0.84-0.90 mol of alkali per 1 mol of polymethylsiloxane contained in methylsilanetriol, adding an electrolyte in an amount of 0.025-0.1 mol per 1 mol of alkali. The resulting polymethylsiloxane polyhydrate has the supramolecular properties of a molecular capsule.

## Claims

### Claim 1

A method for producing a polymethylsiloxane polyhydrate having supramolecular properties of a molecular capsule, the method comprising:
mixing an alkali and polymethylsiloxane contained in methylsilanetriol at a temperature above 90° C. and in a ratio of 0.84-0.9 mol of alkali per 1 mol of polymethylsiloxane contained in methylsilanetriol to provide a first mixture,
adding, to said first mixture, an electrolyte in an amount of 0.025-0.1 mol for each mole of alkali to provide a second mixture, and
polycondensing said second mixture with acid.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the electrolyte is lithium, sodium, potassium, ammonium chloride, bromide, iodide, nitrate, nitrite, carbonate, sulfate, sulfite, acetate, oxalate, succinate, formate, citrate, or mixtures thereof.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the alkali is sodium or potassium hydroxide.

### Claim 4 (depends on 1)

A polymethylsiloxane polyhydrate having supramolecular properties produced by the method according to claim 1 with the chemical formula:
in which
q is a value from 60 to 92, from 89 to 134, or from 133 to 241.

### Claim 5 (depends on 4)

A sorbent containing polymethylsiloxane polyhydrate according to claim 4.