Back to results
US 2025/0144590 A1Published application
Methods and systems for monitoring solid-phase stepwise oligonucleotide synthesis
AssigneeCentrillion Technology Holdings Corporation
InventorPaul DENTINGER
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to method of monitoring a solid-phase reaction on a surface of a substrate by taking measurements at a plurality of positions on the surface. Properties of the surface are determined based on the measurements taken. Based on the properties determined, the extent of the solid-phase reaction is determined. This method can be achieved by using an ellipsometer and measuring the changes in thickness of the surface before and after the solid-phase reaction.
Claims38
A method of monitoring a solid-phase reaction on a surface of a substrate, comprising:
- (a) taking a first measurement of a property of the surface at a plurality of positions on the surface before a first reaction on the surface;
- (b) taking a second measurement of the property of the surface at the plurality of positions on the surface after the first reaction on the surface;
- and
- (c) determining a first quality of the first reaction on the surface based on the first measurement and the second measurement.
1 more element
Dependencies are inferred from the claim text.