Systems and methods for internal drug loading for infusion processes
AssigneeEli Lilly and Company
InventorsYun-Chu CHEN, Sarena Delvecchio HORAVA, Coralie Adele RICHARD, Monica Rixman SWINNEY, Yoon YEO
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Abstract
Methods for applying a therapeutic agent coating to an extended-wear device and the systems created thereby are disclosed. For example, a method for coating an extended-wear device using N-TIPS provides therapeutic agent coating for localized treatment in a patient using an extended-wear device for monitoring or treatment of illness or injury, wherein such methods can be used on polymeric films or within polymeric tubes.
Claims21
A method of coating a medical device with a therapeutic agent, the method comprising:
- introducing a solution comprising the therapeutic agent to a surface of the medical device;
- freezing the medical device with the solution so that the therapeutic agent precipitates from the solution;
- and
- washing the medical device with a non-solvent, wherein the precipitated therapeutic agent remains as a coating on the surface of the medical device.
An infusion device for extended wear, the infusion device comprising:
- a base;
- an adhesive configured to couple the base to a skin of a patient;
- and
- a catheter configured to pierce the skin of the patient, wherein the catheter is in fluid communication with a tubing including a therapeutic coating on an inner surface of an inner lumen defined by the tubing, the therapeutic coating disposed on the inner surface of the inner lumen defined by the tubing using N-TIPS.
Dependencies are inferred from the claim text.