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AssigneeBoston Scientific Scimed, Inc.
InventorsRick Dorn, Nicolas Ball-Jones, Joseph Thomas Delaney, JR.
Estimating the term…
In some aspects, the present disclosure provides hydrogels that comprise a crosslinked reaction product of (a) a reactive multi-arm polymer that comprises a plurality of reactive moieties and (b) a multifunctional crosslinking compound which has plurality of complementary reactive moieties that are reactive with the reactive moieties of the reactive multi-arm polymer, the hydrogels comprising hydrolysable moieties as described herein that are dispersed throughout the hydrogels. Other aspects of the present disclosure pertain to reactive multi-arm polymers and multifunctional crosslinking compounds for forming such hydrogels and to crosslinkable systems for forming such hydrolysable hydrogels.
A reactive multi-arm polymer comprising a core region and a plurality of polymer arms having reactive moieties, each polymer arm comprising a polymer segment linked to the core region and one of the plurality of reactive moieties linked to the polymer segment through a hydrolysable linkage selected from a carbonate linkage, an acid anhydride linkage, an imide linkage, a ketal linkage, a carbamate linkage, an organophosphate ester linkage, a silane linkage, an amide linkage, a hydrozonium linkage, an acylhydrozone linkage, an oxime linkage and an amidohydrozone linkage.
A reactive multi-arm polymer comprising a core region and a plurality of polymer arms having reactive moieties, each polymer arm comprising a polymer segment linked to the core region, one of the reactive moieties linked to the polymer segment through a hydrolysable linkage, and an activating group positioned adjacent to the hydrolysable linkage, which increases a rate of hydrolysis of the hydrolysable linkage.
A system for forming a hydrogel composition that comprises (a) a reactive multi-arm polymer comprising a core region and a plurality of polymer arms having reactive moieties, each polymer arm comprising a polymer segment linked to the core region and one of the plurality of reactive moieties linked to the polymer segment and (b) a multifunctional crosslinking compound comprising a plurality of complementary reactive moieties that are reactive with the reactive moieties of the reactive multi-arm polymer, wherein the plurality of complementary reactive moieties are each linked to a remainder of the multifunctional crosslinking compound through a hydrolysable linkage selected from a carbonate linkage, an acid anhydride linkage, an imide linkage, a ketal linkage, a carbamate linkage, an organophosphate ester linkage, a silane linkage, an amide linkage, a hydrozonium linkage, an acylhydrozone linkage, an oxime linkage and an amidohydrozone linkage.
Dependencies are inferred from the claim text.