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US 2025/0144235 A1Published application
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
AssigneeSana Biotechnology, Inc.
InventorSuvi JAIN
Life of this patent
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Abstract
Provided herein are methods of repeated administration of a lipid particle or viral vector, such as for delivery of a payload gene, to a subject.
Claims64
A method of delivering an exogenous agent to a subject, the method comprising:
- administering to a subject a first dose of a targeted lipid particle comprising an exogenous agent, and administering to the subject a second dose of the targeted lipid particle, wherein
- the targeted lipid particle comprises one or more Paramyxovirus envelope proteins, and wherein
- the first and second doses are administered within one month (e.g., within four weeks, within three weeks, within two weeks, within seven days, within six days, within five days, within four days, within three days, within two days, or within one day) of each other.
A method of delivering an exogenous agent to a subject, the method comprising:
- administering to a subject a first dose of a targeted lipid particle comprising an exogenous agent, and administering to the subject a second dose of the targeted lipid particle, wherein
- the targeted lipid particle comprises one or more Paramyxovirus envelope proteins, and wherein
- the second dose is administered (i) on the first day following the first dose or (ii) on the second, third, fourth, fifth, sixth, seventh, fourteenth, twenty-first, or twenty-eighth day following the first dose
Dependencies are inferred from the claim text.