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AssigneeInstituto Butantan
InventorsLuciana Cezar De Cerqueira Leite, Ana Carolina Ramos Moreno, Dunia Del Carmen Rodriguez Soto, Monalisa Martins Trentini
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The present invention refers to the use of recombinant Mycobacterium strains encoding the A subunit of the heat-labile LT toxin from mutated Escherichia coli, in the manufacture of an immunobiological composition for the prevention and/or treatment of cancer in animals. Preferably, the mutation is at position 63 from serine to lysine. The present invention also provides immunobiological compositions comprising said strains for use in the prevention and/or treatment of cancer. At last, the present invention refers to methods for the prevention and/or treatment of cancer, comprising the administration of said strains to a subject in need thereof. In particular, said cancer is bladder cancer.
Use of a recombinant Mycobacterium strain encoding the A subunit of the heat-labile LT toxin from mutated Escherichia coli characterized in that it is for the manufacture of an immunobiological composition for the treatment and/or prevention of cancer.
Dependencies are inferred from the claim text.