# US 2025/0143983 A1 · Peroxymonosulfate Oral Whitening Compositions > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2025/0143983 A1 - Document ID: US20250143983A1 - Status: Published application - Kind: A1 - Application number: 19/018,357 - Filed: 2025-01-13 - Published: 2025-05-08 - Earliest claimed: 2021-12-23 - Assignees: Colgate-Palmolive Company - Applicants: Colgate-Palmolive Company - Inventors: Cajetan DOGO-ISONAGIE; Suman CHOPRA - Web page: https://patentgrep.com/patent/US20250143983A1 ## CPC - A61K 8/23: Sulfur; Selenium; Tellurium; Compounds thereof - A61K 8/24: Phosphorous; Compounds thereof - A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof - A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate} - A61K 8/8111: {Homopolymers or copolymers of aliphatic olefines, e.g. polyethylene, polyisobutene; Compositions of derivatives of such polymers} - A61K 8/8176: {Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers} - A61K 8/8182: {Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers} - A61K 8/86: Polyethers - A61K 8/90: Block copolymers (A61K8/89 takes precedence) - A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses - A61Q 11/02: Preparations for deodorising, bleaching or disinfecting dentures - A61K 2800/43: Pigments; Dyes - A61K 2800/48: Thickener, Thickening system - A61K 2800/52: Stabilizers - A61K 2800/522: Antioxidants; Radical scavengers - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present disclosure provides tooth whitening oral care compositions comprising potassium peroxymonosulfate having improved stability, and methods of using the same. ## Claims ### Claim 1 A tooth whitening oral care composition comprising 0.01-10% potassium peroxymonosulfate by weight, stabilized with a combination of 21-60% calcium pyrophosphate (Ca2P2O7) and/or insoluble sodium metaphosphate ([NaPO3]n), by weight of the composition, and 20-60% polyoxyethylene/polyoxypropylene triblock copolymer, by weight of the composition. ### Claim 2 (depends on 1) The composition of claim 1, wherein the potassium peroxymonosulfate is the only oxidizing agent present in the composition. ### Claim 3 (depends on 1) The composition of claim 1, wherein the composition is stabilized by 21-60% calcium pyrophosphate (Ca2P2O7), by weight of the composition. ### Claim 4 (depends on 3) The composition of claim 3, wherein the composition comprises the calcium pyrophosphate in an amount of 22% to 60%, or 22% to 50%, or 22% to 40%, or 22% to 35%, or 25% to 60%, or 25% to 50%, or 25% to 40%, or 25% to 35%, or 25% to 30%, or 21% to 30%, or 22% to 30%, or 22.5% to 27.5%, or 23% to 27%, or 24% to 26%, or about 25%, by weight of the composition. ### Claim 5 (depends on 1) The composition of claim 1, wherein the polyoxyethylene/polyoxypropylene triblock copolymer is a triblock copolymer having the formula HO—[CH2CH2O]a[—CH(CH3)CH2O—]b[CH2CH2O]a—H, wherein a is an integer between 1 and 30, b is an integer between 10 and 60. ### Claim 6 (depends on 1) The composition of claim 1, wherein the composition further comprises one or more of polyvinylpyrrolidone, polyethylene glycol/polypropylene glycol random copolymer, polyethylene glycol, polyphosphates (e.g., alkali metal polyphosphates), and surfactants (e.g., anionic and/or zwitterionic surfactants). ### Claim 7 (depends on 1) The composition of claim 1, wherein the composition comprises a mixture of anionic and zwitterionic surfactants. ### Claim 8 (depends on 7) The composition of claim 7, wherein the composition comprises a mixture of sodium lauryl sulfate and cocamidopropyl betaine. ### Claim 9 (depends on 8) The composition of claim 8, wherein the composition comprises 2 to 4%, or 1 to 3%, or 2 to 3%, or 1.5 to 2.5%, or 2 to 2.5%, or about 2%, of sodium lauryl sulfate, and 0.1 to 1%, or 0.1 to 0.5%, or about 0.3%, of cocamidopropyl betaine, by weight of the composition. ### Claim 10 (depends on 1) The composition of claim 1, wherein the composition further comprises an antioxidant, e.g., selected from butylated hydroxyanisole, butylated hydroxytoluene, vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, and mixtures thereof. ### Claim 11 (depends on 1) The composition of claim 1, wherein the composition comprises the potassium peroxymonosulfate in an amount of 1% to 5%, and the composition is stabilized by a combination of 20-40% calcium pyrophosphate and 25-50% of a polyoxyethylene/polyoxypropylene triblock copolymer having the formula HO—[CH2CH2O]a[—CH(CH3)CH2O—]b[CH2CH2O]a—H, wherein an integer between 10 and 12 (e.g., 11), and b is an integer between 15 and 20 (e.g., 16), e.g., the polymer is Pluronic L35, each by weight of the composition. ### Claim 12 (depends on 1) The composition of claim 1, wherein the composition comprises the potassium peroxymonosulfate in an amount of 1% to 3%, and the composition is stabilized by a combination of 20-30% calcium pyrophosphate and 25-35% of a polyoxyethylene/polyoxypropylene triblock copolymer having the formula HO—[CH2CH2O]a[—CH(CH3)CH2O—]b[CH2CH2O]a—H, wherein an integer between 10 and 12 (e.g., 11), and b is an integer between 15 and 20 (e.g., 16), e.g., the polymer is Pluronic L35, each by weight of the composition. ### Claim 13 (depends on 1) The composition of claim 1, wherein the composition further comprises polyvinylpyrrolidone in an amount of 1 to 10%, and PEG/PPG random copolymer having an average molar ratio of ethylene glycol units (EG) to propylene glycol units (PG) of about 105-125 EG to 55-75 PG (e.g., Pluracare L1220 polymer) in an amount of 6 to 15%, and polyethylene glycol 600 in an amount of 5 to 20%, each by weight of the composition. ### Claim 14 (depends on 1) The composition of claim 1, wherein the composition further comprises 2% to 5% tetrasodium pyrophosphate and 0.5 to 1.5% disodium pyrophosphate, by weight of the composition. ### Claim 15 (depends on 1) The composition of claim 1, wherein the composition further comprises a blue dye or pigment, e.g., Blue 15 pigment (also known as CI 74160), optionally in an amount of 0.001 to 0.1% by weight of the composition, e.g., 0.01 to 0.08%, or 0.03 to 0.07%, or about 0.05%, by weight of the composition. ### Claim 16 (depends on 1) A composition according to claim 1, wherein the composition comprises: Ingredient Weight % Potassium peroxymonosulfate 0.1-5% (e.g., 1%) Calcium pyrophosphate 20-30% (e.g., 25%) PEG/PPG triblock copolymer (e.g., 25-35% (e.g., 31%) Pluronic L35) Polyvinylpyrrolidone 1-15% (e.g., 5%) PEG-PPG random copolymer (e.g., 6-15% (e.g., 10%) PEG/PPG-116/66) Polyethylene glycol (e.g., PEG 600) 10-20% (e.g., 12.5%) Polyphosphate (e.g., sodium pyrophosphates) 2.5-5% (e.g., 4%) Anionic Surfactant (e.g., sodium lauryl sulfate) 1-5% (e.g., 2%) Zwitterionic Surfactant (e.g., cocamidopropyl 0.1-1% (e.g., 0.3%) betaine) Fluoride source (e.g., sodium 0.1 to 2% (e.g., 0.75%) monofluorophosphate) Antioxidant (e.g., BHT) 0 to 0.3% (e.g., 0.03%) Thickener (e.g., fumed silica) 2.5-5% (e.g., 4%) Sweeteners and Flavors 0.5-5% Blue pigment or dye (e.g., Blue 15) 0.001 to 0.1% (e.g., about 0.05%) Total ca. 100 ### Claim 17 (depends on 1) The composition according to claim 1, wherein the composition is a dentifrice, e.g., a toothpaste or tooth gel. ### Claim 18 (depends on 1) A method for whitening teeth comprising the steps of (a) applying a composition according to claim 1, to the teeth, and (b) maintaining contact of the composition with the teeth for a sufficient period of time (e.g., 0.1 to 60 minutes, or 0.1 to 30 minutes, or 0.1 to 10 minutes, or 0.1 to 5 minutes, or 0.1 to 2 minutes, or 0.1 to 1 minute) to effect whitening of the teeth contacted by the composition.