Endoscopic, percutaneous and other methods for dissolution of pancreatic necrosis

A dissolution solution comprising between about 0.5% to about 5% hypochlorite and one or more of a gel formulation, a foam formulation, and combinations thereof, wherein:

• (a) the dissolution solution comprises one or more dissolution compounds selected from chlorine dioxide, hydrogen peroxide, eusol (chlorinated lime in boric acid), ethylenediaminetetraacetic acid (EDTA), formocresol (formaldehyde, cresol, glycerin), glutaraldehyde, one or more proteolytic enzymes, peracetic acid, chlorhexidine, Ca hypochlorite, and papain gel, wherein the one or more proteolytic enzymes optionally include a collagenase;
• (b) the gel formulation comprises one or more components selected from an alginic acid, a cellulosic-based compound, a lectin-like cytoadhesive, gellan gum, polycarbophil, carbomer, chitosan, xanthan gum, cyclomethicone, a poloxamer, polyethylene oxide, carrageenan, carboxymethylcellulose, ammonium alginate, sodium alginate, potassium alginate, calcium alginate, poly(methyl vinyl ether/maleic anhydride) ethyl cellulose, propylene glycol, sodium hyaluronate, agar, dextran hydroxypropyl cellulose, croscarmellose sodium, dimethyl-beta-cyclodextrin, povidone, methylcellulose, potassium alginate, pectin, an aliphatic polyester, ceresin, a polyoxyethylene alkyl ester, ceratonia, gelatin, propylene glycol alginate, polyvinyl alcohol, hydroxyethyl methyl cellulose polyoxyl hydroxystearate, and guar gum;
• (c) the dissolution solution further comprises an excipient selected from glyceryl monooleate, lecithin, oleic acid, a dibutyl sebacate salt, sodium chloride, one or more preservatives, glycerin, chlorhexidine, dimethyl sulfoxide, glyceryl behenate, sodium stearate, glyceryl palmitostearate, olive oil, and sucrose stearate;
• (d) the foam formulation comprises one or more of a pharmaceutically acceptable vehicle, a surfactant, a propellant, a stabilizing polymer, and a buffer, wherein optionally (i) the pharmaceutically acceptable vehicle comprises propylene glycol and water;
• (ii) the surfactant is a polysorbate or a sorbitan ester;
• (iii) the propellant is selected from isobutane, propane, air, carbon dioxide, and combinations thereof;
• (iv) the stabilizing polymer is a poloxamer;
• (v) the buffer is a phosphate or a citrate buffer;
• (e) the foam formulation comprises one or more components selected from a solvent, a foaming agent, a foam stabilizer, a hydrophobic component and/or emollient, an absorption promoter, a foam breaker, and an antifoaming agent, wherein optionally (i) the solvent is selected from distilled water, ethanol, isopropanol, glycerin, propylene glycol, dimethyl isosorbide, and dimethyl sulfoxide (DMSO);
• (ii) the foaming agent is selected from cetyl alcohol, cetyl stearyl alcohol, sodium docecyl sulfate, sodium oleate, sodium stearate, stearic acid, and polysorbate 20;
• (iii) the foam stabilizer is selected from xanthan gum, guar gum, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose methyl cellulose, agar-agar, alginates, sodium lauryl sulfate, lauryl acid, palmitic acid, stearic acid, coconut oil, tragacanth gum, gelatin, and glycerin;
• (iv) the hydrophobic component and/or emollient is selected from a mineral oil, a plant oil, an ester, an essential oils, petrolatum, omega-3 polyunsaturated oil, and silicon oil;
• (v) the absorption promoter is selected from ethanol, a fatty acid, and a fatty alcohol;
• (vi) the foam breaker is selected from an alkyl polysiloxane, an oil, an alcohol, a fatty alcohol, and acetone;
• (vii) the antifoaming agent is selected from silicone oil, a glyceride, and polyamide;
• (f) the foam formulation comprises one or more components selected from NaClO, cetyl alcohol, a polysorbate, glycerin, a polyvinylpyrrolidone, a hydroxypropyl methylcellulose (HPMC), and water;
• (g) the foam formulation comprises between about 0.5% to about 5% NaClO, between about 0.1% to about 3.0% cetyl alcohol, between about 0.1% to about 2.5% of a polysorbate, between about 2.0% to about 6.0% glycerin, between about 0.0% to about 3.0% of a polyvinylpyrrolidone, between about 0.0% to about 3.0% of a hydroxypropyl methylcellulose (HPMC), and water;
• and/or
• (h) the foam formulation comprises about 3.5% NaClO, about 0.5% cetyl alcohol, about 0.5% of a polysorbate, about 5.0% glycerin, between about 0.0% to about 3.0% of a polyvinylpyrrolidone, between about 0.0% to about 0.3% of a hydroxypropyl methylcellulose (HPMC), and water.