# US 2025/0143359 A1 · Compounds that modulate gpr92 receptor activity and pet food products containing the same

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- Number: US 2025/0143359 A1
- Document ID: US20250143359A1
- Status: Published application
- Kind: A1
- Application number: 18/984,941
- Filed: 2024-12-17
- Published: 2025-05-08
- Earliest claimed: 2018-09-07
- Assignees: Mars, Incorporated
- Applicants: Mars, Incorporated
- Inventors: Scott Joseph McGrane; Matthew Ronald Gibbs; Carlos Juan Hernangomez de Alvaro; Jerry Wallace Skiles
- Web page: https://patentgrep.com/patent/US20250143359A1

## CPC

- A23L 27/202: {Aliphatic compounds}
- A23K 20/105: Aliphatic or alicyclic compounds
- A23K 50/40: for carnivorous animals, e.g. cats or dogs
- A23K 50/42: Dry feed
- A23K 50/48: Moist feed
- A23L 27/88: {Taste or flavour enhancing agents}
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A23K: FODDER

## Abstract

A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR92 receptor that can be used to enhance palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

## Claims

### Claim 1

A flavor composition comprising a compound of Formula II comprising the structure:
or any salt thereof,
wherein R is a substituted or unsubstituted hydrocarbon chain having a carbon length of between about C2 and about C40.

### Claim 2 (depends on 1)

The flavor composition of claim 1, wherein the hydrocarbon chain comprises zero to eight double bonds.

### Claim 3 (depends on 2)

The flavor composition of claim 2, wherein one or more double bond is substituted with hydrogen, methyl, or C1 to C12 alkyl.

### Claim 4 (depends on 1)

The flavor composition of claim 1, wherein one or more of the carbons in the hydrocarbon chain is substituted by an oxygen, sulfur, nitrogen, ketone, sulfone, sulfoxide, amide, urea, or sulfonamide.

### Claim 5 (depends on 1)

The flavor composition of claim 1, wherein R is a substituted hydrocarbon chain that is substituted with one or more of H, CH3, C1-C20 alkyl, COOH, SO3H, CHO, C(O)R1, C≡CR1R2, C≡NOH, OP(O)(OR1)(OR2), OR1, SR1, CN, COOR1, CONR1R2, NO2, NHOH, F, Cl, Br, I, and NR1R2, wherein R1 and R2 are each independently selected from H and branched or unbranched C1-C6 alkyl.

### Claim 6 (depends on 1)

The flavor composition of claim 1, wherein the compound is selected from the group consisting of 9Z-octadecenyl phosphate, sphingosine-1-phosphate, 1-mercaptoundecylphosphoric acid, trans,trans-farnesyl monophosphate, and any analog or derivative thereof, and any combination thereof.

### Claim 7 (depends on 1)

A food product comprising the flavor composition of claim 1, wherein the flavor composition is present in an amount effective to increase the palatability of the food product.

### Claim 8 (depends on 7)

The food product of claim 7, wherein the flavor composition is present at a concentration of from about 10 pM to about 1 M in the food product.

### Claim 9 (depends on 7)

The food product of claim 7, wherein the flavor composition is present at a concentration of from about 0.01 ppm to 1,000 ppm in the food product.

### Claim 10 (depends on 7)

The food product of claim 7, wherein the flavor composition is present at a concentration of from about 0.01% to about 10% w/w in the food product.

### Claim 11 (depends on 7)

The food product of claim 7, wherein the flavor composition comprises one or more purified compound, and the flavor composition is present at a concentration of from about 1 nM to about 0.1 M in the food product.

### Claim 12 (depends on 7)

The food product of claim 7, wherein the flavor composition comprises peptone or fish hydrolysate, and the flavor composition is present at a concentration of from about 0.1% to about 10% in the food product.

### Claim 13 (depends on 7)

The food product of claim 7, wherein the food product comprises a pet food product.

### Claim 14 (depends on 7)

The food product of claim 7, wherein the pet food product is a feline pet food product or a canine pet food product.

### Claim 15 (depends on 14)

The food product of claim 14, wherein the pet food product is a wet pet food product.

### Claim 16 (depends on 14)

The food product of claim 14, wherein the pet food product is a dry pet food product.