Anti-pten rna interference oligonucleotides and uses thereof
AssigneeNurexone Biologic Ltd.
InventorsNisim PERETS, Lyora AHARONOV, Lior SHALTIEL, Josef MOGRABI
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Abstract
The present invention provides RNA interference (RNAi) oligonucleotides inhibiting expression of Phosphatase and tensin homolog (PTEN), extracellular vesicles comprising the RNAi oligonucleotides, pharmaceutical compositions including the RNAi oligonucleotides or said extracellular vesicles and their use in the treatment of neurological and CNS disorders and, more particularly to their use for the treatment of spinal cord injuries.
Claims27
An RNA interference (RNAi) oligonucleotide selected from siRNA and shRNA, comprising a guide strand comprising a nucleic acid sequence selected from SEQ ID NO:
- 1-23, wherein the RNAi oligonucleotide inhibits the expression of phosphatase and tensin homolog (PTEN) protein.
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