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US 2025/0136950 A1Published application
Compositions and methods for efficient in vivo delivery
AssigneeNvelop Therapeutics, Inc.
InventorsThomas Joseph Cahill, III, Philip Joaquim DeSouza, Peter Cabeceiras
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Abstract
Disclosed herein, in aspects, are compositions, methods, kits, and systems relating to efficient delivery of freights (e.g., therapeutic freights) into cells, for instance, for in vivo delivery.
Claims21
1-89. (canceled)
A lipid containing particle comprising:
- a virally derived glycoprotein selected from the group consisting of:
- RD 114, Fug-E, FuG-E (P440E), and MLV 10A1;
- a combinatorial protein comprising a plasma membrane localization protein coupled to a nuclear export sequence (NES) or a cleavable linker;
- and
- a freight.
2 more elements
A lipid containing particle comprising
- (a) a human endogenous retroviral (HERV) envelope protein, a humanized envelope protein, or a non-immunogenic membrane-fusion molecule;
- (b) a combinatorial protein comprising a plasma membrane localization protein, wherein the plasma membrane localization protein is selected from the group consisting of:
- Pleckstrin homology (PH) domain of Human Daap1, PH domain of Mouse Grp1, PH domain of Human Grp1, PH domain of Human OSBP, PH domain of Human Btk, PH domain of Human FAPP1, PH domain of Human CERT, PH domain of Human PKD, PH domain of Human PHLPP1, PH domain of Human SWAP70, and PH domain of Human MAPKAP1;
- and
- (c) a freight.
2 more elements
A lipid containing particle comprising
- (a) a lipid bilayer comprising an envelope protein or a glycoprotein and an immunosuppressive molecule;
- and
- (b) a combinatorial protein encapsulated by the lipid bilayer comprising a plasma membrane localization protein fused to a freight.
Dependencies are inferred from the claim text.