Methods for reactive crystallisation
AssigneeMicropore Technologies Limited
InventorsMatt Bennett, Elina Beveniou, Alex Kerr, David Hayward
Life of this patent
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Abstract
There is described a method of preparing solid particles of a material, said method comprising controlling provision of a first liquid phase, wherein said first liquid phase comprises a solution of a first material through a membrane, said membrane defining a plurality of pores; and controlling provision of a second liquid phase, wherein said second liquid phase comprises a solution of a second material; reacting the first a second materials to produce a third liquid phase comprising a solution of a third material; and supersaturating the third liquid phase to form solid particles of the third material.
Claims36
A method of preparing solid particles of a material, said method comprising controlling provision of a first liquid phase, wherein said first liquid phase comprises a solution of a first material through a membrane, said membrane defining a plurality of pores;
- and controlling provision of a second liquid phase, wherein said second liquid phase comprises a solution of a second material;
- reacting the first a second materials to produce a third liquid phase comprising a solution of a third material;
- and supersaturating the third liquid phase to form solid particles of the third material.
A method of preparing solid particles of a material, said method comprising controlling provision of a first liquid phase, wherein said first liquid phase comprises a solution of a first material, in a first flow direction to a membrane, said membrane defining a plurality of pores;
- and
- controlling provision of a second liquid phase, wherein said second liquid phase comprises a solution of a second material;
- introduction of the second liquid phase being substantially perpendicular to the introduction of the first liquid phase;
- reacting the first and second materials to produce a third liquid phase comprising a solution of a third material;
- and
- supersaturating the third liquid phase to form solid particles of the third material.
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A method of reactive preparation of solid particles of a third material, said method comprising reacting a first liquid phase with a second liquid phase by dispersing the first liquid phase in the second liquid phase;
- wherein said first liquid phase comprises a solution of a first material and said second liquid phase comprises a solution of a second material;
- said method comprising controlling provision of the first liquid phase in a first flow direction to a membrane, said membrane defining a plurality of pores;
- and controlling provision of the second liquid phase to the membrane in a crossflow (AXF) to the first flow direction, via the plurality of pores, to reactively form a solution of a third material;
- and
- optionally supersaturating the solution of the third material in order to produce particles of the third material.
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-14. (canceled)
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A method according to claim 1817 wherein the solution comprises a pharmaceutically active compound of low bioavailability.
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25-35. (canceled)
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A method according to claim 14 wherein a plurality of membranes is grouped as a cluster of membranes positioned alongside each other.
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A method according to claim 81 wherein the furcation plate is a bi-furcation plate or a tri-furcation plate.
-67. (canceled)
A reactive crystallisation apparatus for reactively dispersing a first phase in a second phase, comprising:
- a membrane defining a plurality of apertures connecting a first liquid phase, wherein said first liquid phase comprises a solution of a first material, on a first side of the membrane;
- to a second liquid phase, wherein said second liquid phase comprises a solution of a second material, on a second different side of the membrane;
- the apparatus being adapted to generate a reactive mixture through egression of the first liquid phase into the second liquid phase via the plurality of apertures;
- the apparatus also comprising a reaction chamber arranged to receive the first and second liquid phases and/or the reactive mixture from the membrane.
-73. (canceled)
Dependencies are inferred from the claim text.