Enhanced mucous adhesion via a complex of carboxymethyl starch and pullulan polymers

Abstract

Compositions and methods of using and manufacturing a pharmaceutical powder and a pharmaceutical hydrogel are provided. The pharmaceutical powder may form a gel after the addition of water. The gel may form a protective film upon drying that can coat the site of application. The protective film may reform a gel after the addition of water to facilitate cleaning and easy removal from the application surface. The pharmaceutical powder and pharmaceutical hydrogel may include pullulan (e.g., in an amount of from about 1 wt. % to about 30 wt. %) and sodium carboxymethyl starch (e.g., in an amount of from about 2 wt. % to about 50 wt. %). The pharmaceutical powder and pharmaceutical hydrogel improve mucoadhesion and wound adhesion and may be combined with active pharmaceutical ingredients (APIs) to treat mucous membrane or dermal diseases or wounds.

Dependencies are inferred from the claim text.