Metap2 inhibitors and uses thereof

A compound of the general formula (I):

• wherein
• R is a carbocyclyl comprising a ring structure of two or more rings, selected from wherein the carbocyclyl group is an adamantly or a derivative thereof;
• a norbornanyl or a derivative thereof;
• a norbornenyl or a derivative thereof;
• a norbornenyl or a derivative thereof;
• a steroidyl or a derivative thereof;
• a camphoryl or a camphor derivative;
• a camphenyl or a camphene derivative;
• a tricyclo(2.2.1.0(2,6))heptanyl or a derivative thereof;
• or a tetracyclo[3.2.0.0(2,7).0(4,6)]heptanyl or a derivative thereof.