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US 2025/0129015 A1Published application
Halogenated benzylidine derivatives
AssigneeRenovel Innovations, Inc.
InventorsBishwajit NAG, Ananda SEN, Nitish NAG, Arjun SANYAL, Srinivasan Narasimhan
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Abstract
Novel Halogenated Benzylidine derivatives are provided which exhibit activity for the treatment of immunological diseases and inflammation
Claims13
A compound of formula (I) including the analogs, tautomeric forms, stereoisomers, polymorphs, and pharmaceutically acceptable salts thereof,
- wherein X is a halogen and Y is selected from the group consisting of a hydrogen, a halogen, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group and a sulfonyl group, and
- wherein the groups represented by R1 and R3 are selected from the group consisting of linear or branched, substituted or unsubstituted (C1 to C12)alkyl groups, and substituted or unsubstituted (C1 to C12)alkoxy groups, and
- wherein R4 is selected from the group consisting of alaninie, glycine, arginine, aspargine, cysteine, glutamic acid, glutamine, histidine, isoleucine, leucine, lysine, methionine, ornithine, proline, serine, threonine, tryptophan, and tyrosine, which may be unsubstitited or substituted, and their derivatives such as ester and amides of carboxylic acid.
A method for the preparation of halogenated benzylidene derivatives of formula (I),
- wherein X is a halogen and Y is selected from the group consisting of a hydrogen, a halogen, a hydroxyl group, a nitro group, a cyano group, a formyl group, an amino group and a sulfonyl group, and wherein the groups represented by R1 and R3 are selected from the group consisting of linear or branched, substituted or unsubstituted (C1 to C12)alkyl groups, and substituted or unsubstituted (C1 to C12)alkoxy groups, and wherein R4 is selected from the group consisting of alaninie, glycine, arginine, aspargine, cysteine, glutamic acid, glutamine, histidine, isoleucine, leucine, lysine, methionine, ornithine, proline, serine, threonine, tryptophan, and tyrosine, which may be unsubstitited or substituted, and their derivatives such as ester and amides of carboxylic acid,
- wherein said method comprises the reaction as follows:
Dependencies are inferred from the claim text.