Implantable and refillable drug delivery reservoir system with porous metal frit for sustained intracerebroventricular delivery and methods of use

Abstract

A device for delivery of a drug into cerebrospinal fluid of a brain including a hollow container having a reservoir volume and an outlet, the container having an upper surface and a lower surface; a porous structure having a sintered rigid material that passively regulates diffusion of a drug from the container at a controlled release rate; and a catheter coupled to a lower end of the container, the catheter having a lumen, a proximal end region, and a distal end region, the lumen configured to communicate with the reservoir volume of the container through the porous structure. Related systems and methods are provided.

Dependencies are inferred from the claim text.